Signs of infections and reduced immune functions at weaning of conventionally reared and specific pathogen free pigs

Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B
E WattrangC Fossum

Abstract

The growth rate and several immune parameters were recorded to monitor the performance, health and immune status of 40 piglets in a conventional farrow to finish herd. In addition, effects of weaning on immune parameters were studied under minimal influence of infections in 20 specific pathogen free (SPF) pigs. The growth rate of the conventionally reared pigs decreased after weaning and after allocation of pigs to new premises. Around weaning a considerable number of pigs displayed interferon-alpha (IFN-alpha) in serum, indicating the spread of viral infections. Bacterial infections were indicated by elevated numbers of circulating neutrophilic granulocytes during the weaning period. Functional in vitro tests of peripheral blood mononuclear cells (PBMC) revealed that the Concanavalin A (Con A) induced proliferation decreased both after weaning and after transfer of the conventionally reared pigs to the finishing unit. The decreased proliferation observed after weaning was accompanied by decreased interleukin-2 (IL-2) production in response to the mitogen. A reduced IL-2 producing capacity after weaning was confirmed with PBMC obtained from the SPF pigs. Flow cytometric analyses of these cells showed that the proportion of PBMC...Continue Reading

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Citations

Jun 8, 2002·Veterinary Immunology and Immunopathology·Elin JohanssonC Fossum
Mar 14, 2001·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·L MelinP Wallgren
Apr 7, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Barbara BegniDamiano Podavini
Mar 14, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Massimo Amadori
Feb 11, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Massimo AmadoriMonica Colitti
Jun 20, 2008·Acta Veterinaria Scandinavica·Taina M LaineMarjukka Anttila
Mar 26, 2013·Research in Veterinary Science·Wageha A AwadJürgen Zentek
Jun 6, 2009·Research in Veterinary Science·Massimo AmadoriMaura Ferrari
Jul 22, 2004·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·S FragouI Politis
Mar 5, 2004·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·L MelinP Wallgren
Oct 19, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Elisabetta RazzuoliMassimo Amadori
Jun 19, 2002·The Proceedings of the Nutrition Society·M BaileyC R Stokes
Dec 2, 2010·Pharmacognosy Magazine·Wei Kun-HuaHuang He-Ping
Jun 26, 2001·Symposium Series·J A Frost

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