Sildenafil and Retinopathy of Prematurity in Preterm Infants with Bronchopulmonary Dysplasia

The Journal of Pediatrics
David AboudiUsha Krishnan

Abstract

To assess whether sildenafil is associated with worsening retinopathy of prematurity (ROP) in very low birth weight (VLBW) infants (≤1500 g) with bronchopulmonary dysplasia (BPD). This retrospective case-control study included VLBW infants admitted to the neonatal intensive care unit between January 1, 2006, and December 31, 2012. Each infant treated with sildenafil was assigned 3 unexposed controls matched for gestational age, birth weight, and BPD diagnosis. Severe ROP was defined as stage ≥3 ROP. Worsening ROP was defined as increased stage of ROP within 8 weeks + 4 days after initiation of sildenafil or matched postmenstrual age. Twenty-three exposed infants and 69 matched controls met the inclusion criteria for the study (mean birth weight, 715 ± 210 g; mean gestational age, 25 ± 1 weeks). The mean postmenstrual age at sildenafil treatment was 42 ± 8 weeks. Exposed infants had more days of respiratory support (mean, 208 ± 101 days vs 102 ± 33 days; P < .001). Exposed infants had a higher prevalence of severe ROP (26% [6 of 23] vs 7% [5 of 69]; OR, 6.4; 95% CI, 1.2-32.9; P = .026). Five exposed infants and 2 unexposed infants had severe ROP before starting sildenafil and were excluded from the analysis for worsening ROP. Th...Continue Reading

Citations

Jan 10, 2020·Journal of Paediatrics and Child Health·Hamish P DunnJames Smith
Feb 20, 2020·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Caren J LiviskieZachary A Vesoulis
Dec 24, 2018·Clinical Medicine Insights. Pediatrics·Zoe MichaelHelen Christou
Jun 7, 2021·European Journal of Pediatrics·Feriel FortasDaniele De Luca
Jul 30, 2021·Pediatric Pulmonology·Gustavo RochaInês Azevedo

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