Sildenafil citrate does not alter ventricular repolarization properties: novel evidence from dynamic QT analysis

Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
Dayimi KayaCetin Dincel

Abstract

Sildenafil citrate may have direct cardiac electrophysiological effects, and is possibly responsible for some cardiac events. The aim of our study was to investigate the effects of sildenafil citrate on QT dynamicity properties with a new QT analysis program showing even small changes in ventricular repolarization. Twenty-four-hour Holter electrocardiographic recordings were used to obtain the data in the predrug phase (1-hour rest position before drug administration), and in the postdrug phase (1-hour rest position, which began 60 minutes after 50 mg oral sildenafil citrate administration). With the special QT analysis program (Verda, Reynolds Medical Ltd., UK); mean values of RR, QT, QTo (corrected QT), J (the exponent of correction formula) and S (QT/RR plots slope) parameters together with QT variability indexes (QTVI) were calculated for study phases. Mean +/- SEM values for RR and QT were higher in postdrug phase than in predrug phase (RR: 845 +/- 42 ms vs 816 +/- 46 ms, P < 0.05; QT: 371 +/- 8 ms vs 361 +/- 9 ms, P < 0.05). However, sildenafil did not induce any significant change in mean +/- SEM values for QT(o), J, and S in postdrug phase compared with predrug phase (408 +/- 10 ms vs 406 +/- 8 ms, 0.474 +/- 0.030 vs 0....Continue Reading

References

Aug 1, 1996·British Journal of Urology·M BoolellM J Allen
May 15, 1998·The New England Journal of Medicine·I GoldsteinP A Wicker
Sep 30, 1998·Lancet·J FeenstraB H Stricker
Oct 3, 1998·Clinical Pharmacology and Therapeutics·G LandeC Funck-Brentano
Mar 12, 1999·The American Journal of Cardiology·F ExtramianaP Maison-Blanche
Mar 17, 1999·The American Journal of Cardiology·G JacksonM J Allen
Jan 11, 2000·Circulation·B G PhillipsV K Somers
Nov 28, 2001·Circulation·S D Katz, D V Parums
Feb 20, 2002·JAMA : the Journal of the American Medical Association·Adelaide M Arruda-OlsonPatricia A Pellikka
Mar 7, 2002·British Journal of Clinical Pharmacology·Gary J MuirheadJörg Taubel
Mar 7, 2002·British Journal of Clinical Pharmacology·Peter A MilliganMats O Karlsson
Jul 19, 2002·Cardiovascular Research·Chern-En ChiangPhilip Yu-An Ding
Dec 10, 2002·Scandinavian Cardiovascular Journal : SCJ·Ulrik HintzeUNKNOWN DIAMOND Study Group
Jul 10, 2003·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Mete AlpaslanCetin Dincel

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Citations

Feb 3, 2005·Pacing and Clinical Electrophysiology : PACE·Beata SredniawaLech Polonski
Apr 29, 2006·Journal of Cardiovascular Electrophysiology·Krekwit ShinlapawittayatornNipon Chattipakorn
Oct 3, 2006·Urology·Graham JacksonMelvin D Cheitlin
Sep 3, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·K ShinlapawittayatornN Chattipakorn

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