Sildenafil improves vascular endothelial function in patients with cystic fibrosis

American Journal of Physiology. Heart and Circulatory Physiology
Paula Rodriguez-MiguelezRyan A Harris

Abstract

Cystic fibrosis (CF), characterized by defective CFTR function, is associated with multiple systemic complications, including vascular dysfunction. Sildenafil, a phosphodiesterase type 5 inhibitor, not only enhances nitric oxide (NO) metabolism but has been shown to improve CFTR functionality as well. Thus, sildenafil has been proposed as a therapy to improve vascular health in CF; however, its potential therapeutic role has yet to be determined. We sought to investigate the effect of sildenafil on endothelial function in patients with CF. Patients with CF completed a randomized, double-blind, placebo-controlled, crossover study with an acute dose of sildenafil (50 mg) or placebo followed by a 4-wk open-label extension with sildenafil (20 mg/day). Flow-mediated dilation (FMD) was used to evaluate endothelial function before and after treatments. In addition, phosphorylated endothelial NO synthase (pNOS3) and total NOS3 protein expression was determined from endothelial cells that were exposed to plasma from the patients before and after 4 wk of sildenafil treatment. No changes ( P ≥ 0.110) in endothelial function were observed after the acute dose of sildenafil. However, FMD significantly ( P = 0.029) increased after 4 wk of tr...Continue Reading

Associated Clinical Trials

Jul 31, 2019·Jennifer Taylor-Cousar

References

Dec 17, 1992·The New England Journal of Medicine·P A NixonC F Doershuk
Nov 1, 1995·Journal of the American College of Cardiology·T J AndersonA C Yeung
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
Feb 1, 1996·The European Respiratory Journal·R K BrownF J Kelly
Jan 1, 1997·Advances in Pharmacology·A van der VlietC E Cross
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·J Vásquez-VivarK A Pritchard
Aug 12, 1998·BioFactors·C DomínguezA Moreno
Dec 9, 1998·The American Journal of Physiology·A ToussonL M Schwiebert
Oct 18, 2002·Journal of the American College of Cardiology·Julian P J HalcoxArshed A Quyyumi
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·L GeeA K Webb
May 20, 2005·The Journal of Pharmacology and Experimental Therapeutics·Susana LiuZheng Huang
Jan 3, 2006·The American Journal of Cardiology·Arthur L Burnett
Jun 26, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jens F PoschetVojo Deretic
Feb 18, 2009·Acta Physiologica·P M VanhoutteM Feletou
Mar 27, 2010·The International Journal of Cardiovascular Imaging·Yoichi InabaSteven R Bergmann
Mar 31, 2010·Hypertension·Ryan A HarrisRussell S Richardson
Jun 22, 2010·The European Respiratory Journal·B LubambaT Leal
Mar 23, 2011·Cardiovascular Research·Milena A GebskaHunter C Champion
Jun 18, 2011·Journal of Andrology·Ling DeyoungGerald B Brock
Dec 15, 2011·American Journal of Physiology. Endocrinology and Metabolism·Rinrada KietadisornAn L Moens
Apr 17, 2012·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Bob LubambaTeresinha Leal
Apr 25, 2012·Journal of Hypertension·Lorenzo GhiadoniFrancesco Cosentino
Jun 30, 2012·The European Respiratory Journal·Philip H QuanjerUNKNOWN ERS Global Lung Function Initiative
Jul 12, 2012·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Antonela LezoElisabetta Bignamini
Oct 2, 2012·Frontiers in Pharmacology·Sabrina NoelTeresinha Leal
Feb 16, 2013·The American Journal of Medicine·Bryan G SchwartzRobert A Kloner
Jul 4, 2013·European Heart Journal·Marietta CharakidaJohn E Deanfield
Sep 11, 2013·Pediatric Pulmonology·Margarita PérezAlejandro Lucia
Jan 17, 2014·The Lancet. Respiratory Medicine·Barry J PlantScott C Bell
Aug 31, 2014·Free Radical Biology & Medicine·Elizabeth J ReverriFrancene M Steinberg
Sep 30, 2014·International Journal of Molecular Sciences·Leah A GarciaMonica G Ferrini
Dec 4, 2014·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·J L Taylor-CousarJ A Nick
Dec 17, 2014·Journal of Women's Health·Cayce L Harness-BrumleyRaksha Jain
Jan 27, 2015·Current Hypertension Reports·Greg Atkinson, Alan M Batterham
Apr 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Christoph TabelingWolfgang M Kuebler
Apr 17, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Paula Rodriguez-MiguelezRyan A Harris
May 12, 2016·Journal of Visualized Experiments : JoVE·Paula Rodriguez-MiguelezRyan A Harris
May 28, 2016·Postgraduate Medicine·Arash VelayatiWilbert S Aronow
Mar 7, 2017·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Mathieu GruetSamuel Verges

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Citations

Sep 10, 2019·The Cochrane Database of Systematic Reviews·Larry C Lands, Sanja Stanojevic
May 21, 2020·Materials·Fei XingUlrike Ritz
Jul 2, 2020·Pediatric Pulmonology·Siddhartha G KapnadakElisabeth P Dellon
Mar 3, 2020·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Siddhartha G KapnadakRichard H Simon
Oct 27, 2020·Medicine and Science in Sports and Exercise·Paula Rodriguez-MiguelezRyan A Harris
Jun 7, 2021·Lancet·Michal ShteinbergJane C Davies
Jun 19, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·T Spencer PooreEdith T Zemanick
Aug 14, 2021·The European Respiratory Journal·Mathias DeclercqPeter Witters
Apr 9, 2019·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Cassandra C DerellaRyan A Harris
Aug 12, 2019·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·M DeclercqP Witters
Jan 18, 2022·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·FangTing YuanHeSheng Luo

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Methods Mentioned

BETA
blood draw

Clinical Trials Mentioned

NCT02057458

Software Mentioned

LIVEP
ImageJ
SPSS

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