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Sildenafil mediates blood-flow redistribution and neuroprotection after neonatal hypoxia-ischemia

Stroke; a Journal of Cerebral Circulation

Mar 1, 2014

Christiane Charriaut-MarlangueOlivier Baud

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Abstract

The best conceivable treatment for hypoxia-ischemia (HI) is the restoration of blood flow to the hypoxic-ischemic region(s). Our objective was to examine whether boosting NO-cGMP signaling using sildenafil citrate, a phosphodiesterase-type 5 inhibitor, could modify cerebral blood flow a...read more

Mentioned in this Paper

Microglial
Purines
Neuroglia
In Situ Nick-End Labeling
Cyclic GMP
Cell Death
Blood Gas Analysis
Hypoxia-Ischemia, Brain
Inflammation
Carotid Artery Occlusion
1
36
Paper Details
References
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  • Citations17
1234
  • References33
  • Citations17
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Sildenafil mediates blood-flow redistribution and neuroprotection after neonatal hypoxia-ischemia

Stroke; a Journal of Cerebral Circulation

Mar 1, 2014

Christiane Charriaut-MarlangueOlivier Baud

PMID: 24473179

DOI: 10.1161/strokeaha.113.003606

Abstract

The best conceivable treatment for hypoxia-ischemia (HI) is the restoration of blood flow to the hypoxic-ischemic region(s). Our objective was to examine whether boosting NO-cGMP signaling using sildenafil citrate, a phosphodiesterase-type 5 inhibitor, could modify cerebral blood flow a...read more

Mentioned in this Paper

Microglial
Purines
Neuroglia
In Situ Nick-End Labeling
Cyclic GMP
1
36

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References33
  • Citations17
1234
  • References33
  • Citations17
12

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