Sildenafil prevents renal dysfunction in contrast media-induced nephropathy in Wistar rats

Human & Experimental Toxicology
Lais Salles de AlmeidaThiago Melo Costa Pereira

Abstract

Contrast-induced nephropathy (CIN) is an iatrogenic medical event in stable cardiology patients that may lead to acute renal failure. There is no current successful therapy to manage CIN. Increasing evidence in experimental models and humans has suggested that this disease is associated with renal tubular and vascular injury triggered by oxidative stress. Considering the importance of reactive oxygen species (ROS) generation in the pathogenesis of CIN, the goal of the present study was to evaluate the effects of sildenafil on CIN development. Male Wistar rats were divided into control, CIN, and CIN pretreated with sildenafil (50 mg/kg/day). CIN was induced by water deprivation, NG-nitro-L-arginine methyl ester + indomethacin injections (10 mg/kg, intraperitoneally) and intravenous iohexol administration (3 g/kg). Renal function was evaluated through glomerular filtration rate (GFR), renal blood flow (RBF), plasma creatinine, uremia, and proteinuria. Oxidative stress was assessed by flow cytometry for intracellular ROS. Treatment with sildenafil attenuated the marked reduction of GFR and RBF in the CIN group. Moreover, sildenafil treatment in CIN rats reduced plasma creatinine, uremia, and proteinuria. Flow cytometry demonstrate...Continue Reading

References

Sep 1, 1994·The Journal of Clinical Investigation·Y AgmonM Brezis
Nov 7, 2002·The Journal of Biological Chemistry·Ken-ichi SetsukinaiTetsuo Nagano
Nov 18, 2005·The Urologic Clinics of North America·Sharron H Francis, Jackie D Corbin
Jan 19, 2006·American Journal of Physiology. Renal Physiology·H Thomas LeeMihwa Kim
Mar 4, 2006·Experimental Physiology·João Carlos G MagalhãesAna Durce O Paixão
May 1, 1945·The Journal of Clinical Investigation·H W SmithM Graber
Sep 5, 2006·The American Journal of Cardiology·James TumlinUNKNOWN CIN Consensus Working Panel
Jan 11, 2008·Journal of the American Society of Nephrology : JASN·Yukiyo YokomakuAtsunori Kashiwagi
Jun 25, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Luigi RoccoGuiomar Nascimento Gomes
Oct 1, 2008·The Journal of Sexual Medicine·Carlo ForestaDaniela Zuccarello
May 29, 2009·American Journal of Physiology. Renal Physiology·Dae Eun ChoiKang Wook Lee
Jun 27, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Richard J SolomonBrendan J Barrett
Sep 22, 2009·Canadian Journal of Physiology and Pharmacology·Farzad EbrahimiAhmad Reza Dehpour
Dec 8, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Alice M MitchellJeffrey A Kline
Mar 3, 2010·Investigative Radiology·Samuel N HeymanChristian Rosenberger
Apr 1, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Osun KwonTadahiro Uemura
Jun 15, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ozlem OzdegirmenciTayfun Uzbay
May 18, 2011·Basic & Clinical Pharmacology & Toxicology·Badreldin H AliMansour Al-Moundhri
Jul 12, 2011·Journal of Vascular Surgery·John H RundbackVanessa Yoo
Jul 26, 2011·International Journal of Cardiology·Philip Ching Yat WongAidong Zhang
Oct 6, 2011·Circulation. Cardiovascular Interventions·Mauro MaioliFrancesco Bellandi
Oct 11, 2011·The Annals of Thoracic Surgery·Nishith N PatelGavin J Murphy
Jan 24, 2012·European Heart Journal·Erdmann SeeligerPontus B Persson
Jun 13, 2012·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Alice M MitchellJeffrey A Kline
Jun 28, 2012·Molecular Biology Reports·A KüçükS Erkasap
Jun 21, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eric M GeorgeJoey P Granger
Jun 22, 2013·DNA and Cell Biology·Bianca P CampagnaroSilvana S Meyrelles
Oct 5, 2013·Journal of the Chinese Medical Association : JCMA·Chao-Fu Chang, Chih-Ching Lin
Nov 22, 2013·PloS One·Johannes StegbauerEvanthia Mergia
Feb 8, 2014·Journal of Translational Medicine·Ananda T DiasElisardo C Vasquez
May 24, 2014·The American Journal of Medicine·Sumeet GandhiMichael E Farkouh
Jul 6, 2014·The Annals of Pharmacotherapy·Trang H AuDaniel E Hilleman
Aug 15, 2014·Journal of Toxicology·Mohamed A MorsyMagdy K Hassan
Sep 17, 2014·Journal of Translational Medicine·Ananda T DiasElisardo C Vasquez
Dec 20, 2014·TheScientificWorldJournal·Michele AndreucciAshour Michael

❮ Previous
Next ❯

Citations

Sep 18, 2015·Journal of Inflammation·Christina Alves Peixoto, Fabiana Oliveira Dos Santos Gomes
Aug 17, 2016·International Journal of Molecular Sciences·Thiago Melo Costa PereiraElisardo Corral Vasquez
Oct 22, 2020·Journal of Translational Medicine·Prit KusirisinNipon Chattipakorn
Mar 24, 2021·Clinical and Experimental Nephrology·Enis Rauf Coskuner, Burak Ozkan
Jul 6, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Andrei Mihai IordacheDaniela Calina

❮ Previous
Next ❯

Methods Mentioned

BETA
urine sampling
flow cytometry

Software Mentioned

GraphPad
FACSDiva
Prism Prism

Related Concepts

Related Feeds

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Michael HaaseRinaldo Bellomo
Antioxidants & Redox Signaling
Ana I MoralesFernando Pérez-Barriocanal
The Yale Journal of Biology and Medicine
G B AppelJ P Hayslett
Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
Michele Andreucci
© 2022 Meta ULC. All rights reserved