Silence of the centromeres--not

Trends in Biotechnology
Howard J Cooke

Abstract

Centromeres are a conundrum; although many proteins associated with centomeres are conserved from yeast to humans, the underlying DNA sequence is not. A proposed solution to this problem is that an epigenetic, largely heterochromatic, state be imposed by these proteins. Recent analysis of a human neocentromere and the complete sequence of a rice centromere suggest that this epigenetic state can enable transcription of at least some genes within a centromere.

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Citations

Mar 12, 2009·Plant Molecular Biology·Yidan OuyangQifa Zhang
Mar 21, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Shubha VijAkhilesh K Tyagi

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