PMID: 8580707Oct 1, 1995Paper

Silencing is golden: negative regulation in the control of neuronal gene transcription

Current Opinion in Neurobiology
C J Schoenherr, D J Anderson

Abstract

Recent work has identified negative-acting DNA regulatory elements that function to prevent the expression of neuronal genes in non-neuronal cell types or in inappropriate neuronal subtypes. In some cases, the protein factors that interact with these silencer elements have been isolated and characterized. For example, the recently cloned silencer-binding factor NRSF/REST is a novel zinc-finger protein that interacts with silencer elements in a number of neuron-specific genes. These data suggest that negative regulation plays a major role in determining the diverse patterns of gene expression within the nervous system.

References

May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R PossentiA Levi
Sep 14, 1990·Science·E S MonukiG Lemke
Jan 1, 1989·Annual Review of Biochemistry·P F Johnson, S L McKnight
Jun 5, 1987·Science·T ManiatisJ A Fischer
Sep 1, 1987·Molecular and Cellular Biology·D G LeonardL A Greene
Jun 15, 1994·Journal of Neuroscience Research·D E Rincón-LimasP I Patel
Jul 1, 1993·Mechanisms of Development·E S MonukiG Lemke
Dec 1, 1994·Molecular and Cellular Neurosciences·C E KeeganA F Seasholtz
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·P LönnerbergC F Ibáñez
Mar 24, 1995·The Journal of Biological Chemistry·A D AdamsM A Thompson
Jun 1, 1994·Current Opinion in Neurobiology·A J Silva, K P Giese
Sep 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E H Davidson
Feb 1, 1994·Current Opinion in Neurobiology·A L Joyner, F Guillemot
Feb 1, 1994·Current Opinion in Neurobiology·Y N Jan, L Y Jan
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·E S MonukiG Lemke
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·L LiP Greengard

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Citations

Jan 10, 1998·The Journal of Pathology·W ChenH Tiedge
Oct 23, 2002·Journal of Neuroscience Research·Nozomu Mori, Hiroshi Morii
Apr 25, 2012·Cell and Tissue Research·Sajjad Sisakhtnezhad, Maryam M Matin
Jul 9, 2008·Journal of Molecular Neuroscience : MN·Joshua J ParkY Peng Loh
Aug 23, 2002·Brain Research. Molecular Brain Research·Majambu MbikayNabil G Seidah
Feb 5, 1998·Brain Research. Molecular Brain Research·A DobiD V Agoston
Apr 27, 1999·Brain Research. Molecular Brain Research·L S ChinL Li
Jun 25, 1999·Brain Research. Molecular Brain Research·M L Andria, E J Simon
Oct 4, 2002·Hearing Research·David W RobersonDouglas A Cotanche
Feb 1, 1997·Current Opinion in Neurobiology·D C Weinstein, A Hemmati-Brivanlou
Sep 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Elodie Portales-CasamarElizabeth M Simpson
Sep 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Polina KehayovaTom Maniatis
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·C J SchoenherrD J Anderson
Aug 8, 2008·Nucleic Acids Research·Raja JothiKeji Zhao
Aug 27, 2011·Journal of Oncology·Valentina CalderaDavide Schiffer
May 31, 2011·Molecular Brain·Paul R AlbertAnne M Millar
Mar 5, 2009·Disease Models & Mechanisms·Dagmar E EhrnhoeferMichael R Hayden
Nov 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michele YeoWolfgang Liedtke
Dec 1, 2011·Epigenomics·Angela Bithell
Jul 26, 2013·Clinical Neuropathology·Harvey B Sarnat
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y NaruseN Mori
Jul 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Alexander W BruceNoel J Buckley
Jan 9, 2016·Molecular Neurobiology·Yangang ZhaoJiqiang Zhang
Jun 21, 2015·Proceedings of the National Academy of Sciences of the United States of America·Kelan ChenMarnie E Blewitt

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