Silencing lncRNA PVT1 inhibits activation of astrocytes and increases BDNF expression in hippocampus tissues of rats with epilepsy by downregulating the Wnt signaling pathway

Journal of Cellular Physiology
Teng ZhaoWeihong Lin


The aim of this study is to investigate the effects of long-chain noncoding RNA plasmacytoma variant translocation 1 (PVT1) on the activation of astrocytes and the expression of brain-derived neurotrophic factor (BDNF) in hippocampus tissues of epileptic rats. The epilepsy rat model was induced by intraperitoneal injection of lithium chloride-pilocarpine. Successfully modeled rats were grouped, and their spatial learning and memory, neuronal loss, number of TdT-mediated dUTP nick labeling (TUNEL)-positive cells, and the expression of cleaved-caspase-3, pro-caspase-3, Bax, Bcl-2, GFAP, BDNF, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, axin, and cyclin D1 in hippocampus tissues were evaluated. Increased expression of PVT1 was found in hippocampus tissues of epileptic rats. Silencing of PVT1 improved spatial learning and memory, decreased neuronal loss, decreased the number of TUNEL-positive cell, decreased the expression of cleaved-caspase-3 and Bax while increased pro-caspase-3 and Bcl-2 expression, decreased the expression of GFAP, increased the expression of BDNF, decreased the expression of TNF-α, IL-1β, and IL-6, and decreased the expression of axin and cyclin D1 in hippocampus tissues in epileptic rats. O...Continue Reading


Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Nov 4, 2000·Neurochemical Research·L F EngY L Lee
Apr 23, 2003·Journal of Cancer Research and Clinical Oncology·B Lustig, J Behrens
May 2, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Haidong Dong, Lieping Chen
Sep 27, 2003·Acta Neurologica Scandinavica. Supplementum·J W Sander, E Perucca
Apr 25, 2006·Biological Psychiatry·Ronald S Duman, Lisa M Monteggia
Jul 31, 2007·Epilepsia·Jose F Tellez-ZentenoSamuel Wiebe
Aug 30, 2007·Nature Neuroscience·Keri MartinowichBai Lu
Oct 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yinghui GuanJoe W Gray
Nov 8, 2007·Acta Neurologica Scandinavica·T BrommelandV Isaksen
Nov 14, 2007·Brain : a Journal of Neurology·C S JungM Sitzer
Apr 27, 2011·Developmental Medicine and Child Neurology·Pratibha Singhi
Sep 7, 2011·Neurology·Anthony K NgugiC R Newton
Nov 24, 2011·The Journal of Biological Chemistry·Anthony M BarsottiCarol Prives
May 11, 2012·Neurology·M J BrodieP Kwan
Sep 21, 2013·Nature Reviews. Drug Discovery·Wolfgang LöscherDieter Schmidt
Apr 18, 2015·BioMed Research International·Teresa ColomboPaola Paci
Oct 2, 2015·Acta Neuropathologica·Annamaria VezzaniWolfgang Löscher
Oct 3, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qinyi ZhouJiadong Wang
Jun 9, 2016·Journal of Toxicology and Environmental Health. Part a·Xianghu WangRan Liu
Jun 9, 2016·Behavioral and Brain Functions : BBF·Galina Y ZheleznyakovaHelgi B Schiöth
Jan 21, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·W ZhaoZ Cui
May 31, 2017·Pediatrics·Kari Modalsli AabergPål Surén

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