Silencing of CXCR4 blocks progression of ovarian cancer and depresses canonical Wnt signaling pathway

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Jia WangZehua Wang

Abstract

CXC chemokine receptor 4 (CXCR4) was considered to be an important factor in cancer cell metastasis. This study was aimed to examine the expression of CXCR4 in ovarian cancer and determine the functions and the possible mechanisms of CXCR4 in the progression of ovarian cancer. CXC chemokine receptor 4 messenger RNA expression in normal ovarian tissues, malignant epithelial ovarian tumors, and 3 ovarian cancer cell lines was analyzed. Immunohistochemical analysis was used to detect the protein expression of CXCR4 and β-catenin in normal and malignant ovarian tissues. The effect of CXCR4 inhibition on cell proliferation and invasion was determined. CXC chemokine receptor 4 was highly expressed in malignant ovarian tumors and ovarian cancer cell lines, and the different expression of CXCR4 was observed between the ovarian cancers with lymph node metastasis and without lymph node metastasis. Furthermore, The CXCR4 expression was correlated with β-catenin expression in ovarian tissues. Moreover, knockdown of CXCR4 could obviously reduce proliferation and invasion of ovarian cancer cell and inhibit Wnt target genes and mesenchymal markers such as vimentin and SLUG expression. CXC chemokine receptor 4 plays a critical role in the meta...Continue Reading

References

Jan 11, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhi-hua YuYong-tao Gao
Aug 21, 2012·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hai-Ying ChenLexin Wang
Dec 4, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jing GuoDi Ge
Aug 12, 2014·BioMed Research International·Jiamin ZhouJi Ming Wang
Dec 5, 2014·Journal of Experimental & Clinical Cancer Research : CR·Shengqiang ZhaoChengyong Qin
Apr 16, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhidong WangYong Zhou
Apr 26, 2014·Oncology Letters·Karolina Jaszczynska-NowinkaLudwik K Malendowicz

Citations

Apr 12, 2003·The Journal of Biological Chemistry·Gregory HelbigHarikrishna Nakshatri
Mar 23, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J-P SpanoJ-C Soria
Apr 23, 2004·Trends in Immunology·Bernhard MoserPius Loetscher
Nov 16, 2004·Cancer Cell·Yan M LiMien-Chie Hung
Jan 22, 2005·Annals of the New York Academy of Sciences·Carola PorcileGennaro Schettini
Mar 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stefania ScalaGiuseppe Castello
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Jean Paul Thiery, Jonathan P Sleeman
Oct 4, 2006·Cancer Metastasis Reviews·A Ben-Baruch
Jul 17, 2007·Cancer Letters·Dayanidhi RamanAnn Richmond
Jun 11, 2009·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Xiaoyan ShenZehua Wang

Related Concepts

Ovarian Diseases
SNAI2 gene
Biochemical Pathway
Gene Expression Regulation, Neoplastic
VIM gene
Cystadenocarcinoma, Serous
Beta catenin
CXCR4 gene
Ovarian Neoplasm
C-X-C Motif Chemokine 12 Receptor Activity

Related Feeds

Adenocarcinoma, Clear Cell

Clear Cell Adenocarcinoma is a tumor that arises in the female genital tract and is characterized by cells that appear clear under the microscope. Discover the latest research here.