Silencing of DYRK2 increases cell proliferation but reverses CAM-DR in Non-Hodgkin's Lymphoma

International Journal of Biological Macromolecules
Yuchan WangSong He

Abstract

DYRK2, a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase gene, is involved in regulating many processes such as cell proliferation, cell differentiation and cytokinesis. DYRK2 also plays an important role in many cancers, such as breast cancer, non-small cell lung cancer and esophageal adenocarcinomas. In this study, we found that DYRK2 is associated with the proliferation of Non-Hodgkin's lymphoma (NHL) and cell adhesion mediated drug resistance (CAM-DR). Clinically, the mRNA and protein expression levels of DYRK2 are decreased in NHL tissues compared with reactive lymphoid hyperplasia tissues. Immunohistochemical analysis revealed that low expression of DYRK2 is associated with poor prognosis of NHL patients. Interestingly, knockdown of DYRK2 can promote cell proliferation via modulating cell cycle progression. Finally, we demonstrated that DYRK2 plays an important role in CAM-DR by regulating p27(Kip1) expression. Importantly, DYRK2 knockdown reverses CAM-DR in NHL. Our research suggested that DYRK2 may be a novel therapeutic target for NHL.

References

Jan 25, 2002·Genes, Chromosomes & Cancer·Sukvarsha MehraR S K Chaganti
Jan 13, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jul 28, 2012·Lancet·Kate R ShanklandBarry W Hancock
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Jan 21, 2015·Cell Cycle·Naoe Taira Nihira, Kiyotsugu Yoshida
Jan 24, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·Yang ShiJianhua Qin

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Citations

Sep 14, 2019·Blood·Chun Shik ParkH Daniel Lacorazza
May 29, 2020·Cellular and Molecular Life Sciences : CMLS·Alejandro Correa-SáezMarco A Calzado
Jul 6, 2017·Neurochemical Research·Yifen ShenChun Cheng
Dec 31, 2020·The Journal of Biological Chemistry·Vasudha TandonSourav Banerjee

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