Abstract
Hyaluronan synthase 2 (HAS2)-AS1 (natural antisense transcript of HAS2) functions as oncogenic long noncoding RNA (lncRNA) in oral squamous cell carcinoma, breast cancer, and osteosarcoma. The role of HAS2-AS1 in glioma remains unknown. In our research, HAS2-AS1 expression was elevated in glioma tissues compared with normal brain tissues. Moreover, high levels of HAS2-AS1 expression was observed in patients with glioma with high WHO grade (III-IV) or large tumor size ( > 4 cm). The survival analysis from The Cancer Genome Atlas showed glioma cases with high HAS2-AS1 expression that had shorter disease-free survival time and overall survival time than those with low HAS2-AS1 expression. In vitro studies suggested that knocking down HAS2-AS1 expression inhibited glioma cell viability, migration, and invasion through phosphoinositide 3-kinase/protein kinase B signaling pathway. In conclusion, HAS2-AS1 may be considered as a predictor for clinical outcome and a potential therapeutic target in glioma.
References
Apr 22, 2005·The Journal of Biological Chemistry·Hsu Chao, Andrew P Spicer
Jan 28, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Fang ShenLiang-Fu Zhou
Sep 4, 2014·The Journal of Biological Chemistry·Davide VigettiAlberto Passi
Jan 21, 2015·Current Molecular Medicine·V Dimitrova, A Arcaro
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Nov 12, 2016·Scientific Reports·Ben MaQinghai Ji
Jan 26, 2017·Journal of Cellular Biochemistry·Yiwei LiaoLei Cheng
Feb 13, 2017·Gene·Guo-Wen HuHai-Li Lang
Mar 4, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·P D Delgado-LópezM T Dueñas-Polo
Mar 11, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ricky ChenHoward Colman
Apr 13, 2017·Journal of Cancer Research and Clinical Oncology·Yang NanYue Zhong
May 10, 2017·Molecular Carcinogenesis·Guiquan ZhuLing Li
Jul 1, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yan LiGuohua Li
Aug 10, 2017·Frontiers in Pharmacology·Wenyong LongQing Liu
Aug 24, 2017·Bioscience Reports·Peng DuYiwei Liao
Oct 4, 2017·Oncotarget·Moatasem El-AyadiAndre O von Bueren
Oct 8, 2017·World Journal of Surgical Oncology·Qian SunHao Jiang
Oct 20, 2017·Bioscience Reports·Anqiang YangXiaobing Yang
Nov 4, 2017·Current Oncology Reports·Zachary CorbinLawrence Recht
Sep 9, 2018·Matrix Biology : Journal of the International Society for Matrix Biology·Constantinos KolliopoulosParaskevi Heldin
Sep 13, 2018·CA: a Cancer Journal for Clinicians·Freddie BrayAhmedin Jemal
Citations
Aug 11, 2020·Bioscience Reports·Juntong WangDongchun Wang
Mar 22, 2021·The Journal of Biological Chemistry·Matías Arturo PibuelSilvina Laura Lompardía
Oct 17, 2020·Cell Cycle·Juntong WangDongchun Wang
May 11, 2021·Journal of Cellular Biochemistry·Wei LiuLan Wu
Jun 8, 2021·Frontiers in Oncology·Yalin LuQiang Huang
Aug 27, 2021·Matrix Biology Plus·Arianna ParnigoniDavide Vigetti