Silencing of HAS2-AS1 mediates PI3K/AKT signaling pathway to inhibit cell proliferation, migration, and invasion in glioma

Journal of Cellular Biochemistry
Zhenyi ZhaoShijun Feng

Abstract

Hyaluronan synthase 2 (HAS2)-AS1 (natural antisense transcript of HAS2) functions as oncogenic long noncoding RNA (lncRNA) in oral squamous cell carcinoma, breast cancer, and osteosarcoma. The role of HAS2-AS1 in glioma remains unknown. In our research, HAS2-AS1 expression was elevated in glioma tissues compared with normal brain tissues. Moreover, high levels of HAS2-AS1 expression was observed in patients with glioma with high WHO grade (III-IV) or large tumor size ( > 4 cm). The survival analysis from The Cancer Genome Atlas showed glioma cases with high HAS2-AS1 expression that had shorter disease-free survival time and overall survival time than those with low HAS2-AS1 expression. In vitro studies suggested that knocking down HAS2-AS1 expression inhibited glioma cell viability, migration, and invasion through phosphoinositide 3-kinase/protein kinase B signaling pathway. In conclusion, HAS2-AS1 may be considered as a predictor for clinical outcome and a potential therapeutic target in glioma.

References

Apr 22, 2005·The Journal of Biological Chemistry·Hsu Chao, Andrew P Spicer
Jan 21, 2015·Current Molecular Medicine·V Dimitrova, A Arcaro
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Mar 4, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·P D Delgado-LópezM T Dueñas-Polo
Mar 11, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ricky ChenHoward Colman
Jul 1, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yan LiGuohua Li
Aug 10, 2017·Frontiers in Pharmacology·Wenyong LongQing Liu
Oct 4, 2017·Oncotarget·Moatasem El-AyadiAndre O von Bueren
Oct 8, 2017·World Journal of Surgical Oncology·Qian SunHao Jiang
Nov 4, 2017·Current Oncology Reports·Zachary CorbinLawrence Recht
Sep 9, 2018·Matrix Biology : Journal of the International Society for Matrix Biology·Constantinos KolliopoulosParaskevi Heldin

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Citations

Mar 22, 2021·The Journal of Biological Chemistry·Matías Arturo PibuelSilvina Laura Lompardía
Jun 8, 2021·Frontiers in Oncology·Yalin LuQiang Huang

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