Silencing of hSlo potassium channels in human osteosarcoma cells promotes tumorigenesis

International Journal of Cancer. Journal International Du Cancer
Béatrice CambienHeidy Schmid-Antomarchi

Abstract

Potassium channels, the most diverse superfamily of ion channels, have recently emerged as regulators of carcinogenesis, thus introducing possible new therapeutic strategies in the fight against cancer. In particular, the large conductance Ca(2+)-activated K(+) channels, often referred to as BK channels, are at the crossroads of several tumor-associated processes such as cell proliferation, survival, secretion and migration. Despite the high BK channel expression in osteosarcoma (OS), their function has not yet been investigated in this malignant bone pathology. Here, using stable RNA interference to reduce the expression of hSlo, the human pore-forming alpha-subunit of the BK channel, in human Cal72 OS cells, we show that BK channels play a functional role in carcinogenesis. Our results reveal for the first time that BK channels exhibit antitumoral properties in OS in vivo and affect the tumor microenvironment through the modulation of both chemokine expression and leukocyte infiltration.

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Oct 12, 2010·The Journal of Membrane Biology·Nola Jean ErnestSusan E Spiller
Jul 31, 2009·BMC Cancer·Divya KhaitanNagendra S Ningaraj
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Aug 28, 2021·International Journal of Molecular Sciences·Loretta FerreraMichael Pusch

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