Silencing of long non-coding RNA LINC01270 inhibits esophageal cancer progression and enhances chemosensitivity to 5-fluorouracil by mediating GSTP1methylation.

Cancer Gene Therapy
Nuo LiBaoming Wang

Abstract

Esophageal cancer (EC) is a serious digestive malignancy which remains the sixth leading cause of cancer-related deaths worldwide. Emerging evidence suggests the involvement of long non-coding RNAs (lncRNAs) in the tumorigenesis of EC and thus, in this study we explored the potential effects of lncRNA LINC01270 on EC cell proliferation, migration, invasion and, drug resistance via regulation of glutathione S-transferase P1 (GSTP1) methylation. First, we screened out the EC-related differentially expressed lncRNAs, and the expression of our top candidate LINC01270 was quantified in EC tissues and cells. To define the role of LINC01270 in EC progression, we evaluated the proliferation, migration and invasion of EC cells when the LINC01270 was overexpressed or knocked down, in the presence of the GSTP1 methylation inhibitor SGI-1027 and 5-fluorouracil (5-FU). In addition, interaction between LINC01270 and methylation of the GSTP1 promoter was identified. Finally, we assessed transplantable tumor growth in nude mice. LINC01270 was up-regulated and GSTP1 was down-regulated in EC tissues and cells. Silencing of LINC01270 inhibited migration and invasion, and enhanced the sensitivity of 5-FU in EC cells. We found that LINC01270 recrui...Continue Reading

References

Sep 18, 2009·Breast Cancer Research and Treatment·Theodoros N Sergentanis, Konstantinos P Economopoulos
Jul 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J J Emerson, Wen-Hsiung Li
Mar 15, 2011·Urologic Oncology·Yousuke UchidaMasayuki Nakagawa
Apr 15, 2011·Molecular Cancer·Ewan A GibbWan L Lam
Sep 29, 2011·The EMBO Journal·Athanasios ZovoilisAndre Fischer
Mar 13, 2012·Cancer Letters·Andrew M Kaz, William M Grady
Jul 4, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Xuelin ZhangBingxiang Yu
Aug 21, 2012·Molecular Oncology·Hiromu SuzukiMasahiro Kai
Feb 27, 2013·Biochemical and Biophysical Research Communications·Lin Zhu, Pei-Cheng Xu
Jun 25, 2013·Cancer Letters·Xuefei ShiYong Song
Dec 4, 2013·Proceedings of the National Academy of Sciences of the United States of America·Paul MonnierLuisa Dandolo
Feb 18, 2014·Journal of Experimental & Clinical Cancer Research : CR·Xiaobin CuiFeng Li
Jan 3, 2015·Nature Reviews. Genetics·Daniel Holoch, Danesh Moazed
Mar 6, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shumei SongJaffer A Ajani
Jul 18, 2015·World Journal of Gastroenterology : WJG·María José Domper ArnalÁngel Lanas Arbeloa
May 18, 2016·Cell Chemical Biology·Sharon M LouieDaniel K Nomura
Feb 18, 2017·International Journal of Clinical Pharmacology and Therapeutics·Zheng-Qiu ZhuHong-Xing Cai
Mar 21, 2017·Journal of Surgical Oncology·Gautam K MalhotraChandrakanth Are
Apr 27, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Aaliya BhatB A Ganai
May 23, 2017·Gastroenterology·John M Abraham, Stephen J Meltzer
Oct 14, 2017·Cancer Genetics·Weiliang SunJunming Guo
Jul 5, 2018·Journal of Cancer Research and Therapeutics·Yang LiLeijin Mao
May 19, 2019·The International Journal of Biochemistry & Cell Biology·Ming-Jiu ChenZhen-Kun Xia
May 30, 2019·Cancer Biology & Therapy·Yi-Zhi WangJun-Chao Guo

❮ Previous
Next ❯

Citations

Aug 16, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Ganesh Kumar BarikBhargab Kalita

❮ Previous
Next ❯

Methods Mentioned

BETA
RIP
ChIP
transfection
PCR
protein assay
acetylation
immunoprecipitation

Software Mentioned

BrainLAB System
PhyloCSF
peptideatlas
R package edgeR
MethPrimer
R

Related Concepts

Related Feeds

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.