Silencing of p68 and STAT3 synergistically diminishes cancer progression

Life Sciences
Vida HashemiFarhad Jadidi-Niaragh

Abstract

Since several factors are involved in the tumorigenesis process, targeting only one factor most probably cannot overwhelm cancer progression. Therefore, it seems that combination therapy through targeting more than one cancer-related factor may lead to cancer control. The expression and function of p68 (DDX5; DEAD-Box Helicase 5) are dysregulated in various cancers. P68 is also a co-activator of many oncogenic transcription factors such as the signal transducer and activator of transcription-3 (STAT3), which contributes to cancer progression. This close connection between p68 and STAT3 plays an important role in the growth and development of cancer. We decided to suppress the p68/STAT3 axis in various cancer cells by using Polyethylene glycol-trimethyl Chitosan-Hyaluronic acid (PEG-TMC-HA) nanoparticles (NPs) loaded with siRNA molecules. We assessed the impact of this combination therapy on apoptosis, proliferation, angiogenesis, and tumor growth, both in vitro and in vivo. The results showed that siRNA-loaded NPs notably suppressed the expression of p68/STAT3 axis in cancer cells, which was associated with blockade of tumor growth, colony formation, angiogenesis, and cancer cell migration. In addition to apoptosis induction, t...Continue Reading

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Citations

Nov 24, 2020·International Journal of Biological Macromolecules·Vahid KarpishehFarhad Jadidi-Niaragh
Jun 24, 2020·European Journal of Pharmacology·Farnaz HajizadehFarhad Jadidi-Niaragh
May 18, 2020·International Immunopharmacology·Gholamreza Rezaei DanbaranHamed Mohammadi
Apr 4, 2020·International Immunopharmacology·Vida HashemiFarhad Jadidi-Niaragh
Mar 6, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Hendrik Setia BudiFarhad Jadidi-Niaragh
Jun 20, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Ali MasjediFarhad Jadidi-Niaragh
Mar 28, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Sima Emadi AllahyariFarhad Jadidi-Niaragh

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