Silencing the spindle assembly checkpoint: Let's play Polo!

The Journal of Cell Biology
Giorgia Benzi, Simonetta Piatti

Abstract

Silencing of the spindle assembly checkpoint involves two protein phosphatases, PP1 and PP2A-B56, that are thought to extinguish checkpoint signaling through dephosphorylation of a checkpoint scaffold at kinetochores. In this issue, Cordeiro et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202002020) now show that a critical function of these phosphatases in checkpoint silencing is removal of Polo kinase at kinetochores, which would otherwise autonomously sustain the checkpoint.

References

Aug 22, 2012·The Journal of Cell Biology·Dan LiuMichael A Lampson
Sep 24, 2014·The Journal of Cell Biology·Antonio EspertUlrike Gruneberg
Oct 21, 2015·Current Biology : CB·Andrea Musacchio
Mar 8, 2016·Current Opinion in Cell Biology·Banafsheh Etemad, Geert J P L Kops
Jan 10, 2017·Biology·Michael A Lampson, Ekaterina L Grishchuk
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Sep 13, 2019·The Journal of Cell Biology·Daniel HaywardUlrike Gruneberg
Oct 31, 2020·The Journal of Cell Biology·Marilia H CordeiroAdrian T Saurin

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