PMID: 7939517Sep 3, 1994Paper

Silent ischemia--what should be done?

Schweizerische medizinische Wochenschrift
H Gohlke

Abstract

The prevalence of silent, previously undiagnosed, exercise-induced ischemia is between 0.5 und 3.5% in 40-59-year-old men. Its prevalence is dependent upon the prevalence of coronary artery disease in the population or sub-population considered. The pathophysiological mechanism of silent ischemia is extracardiac. The prognosis of silent ischemia is determined by the functional impairement and the extent of coronary artery disease. The decision concerning medical and surgical treatment of patients with silent ischemia is based on the same criteria as in patients with ischemia and angina pectoris: patients at high risk (ischemia at low levels of exercise, marked exercise-induced ischemia, proximal 3-vessel disease and at least moderately impaired left ventricular function) are candidates for invasive treatment. Patients with ischemia at high levels of exercise, or with minimal ischemia with one- or two-vessel disease, are candidates for medical management. The best possible control of all cardiovascular risk factors is mandatory for all patients, from the viewpoint of prognosis in particular.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.