Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 Patients

Journal of Clinical Medicine
Joaquim Bosch-BarreraJavier A Menendez

Abstract

COVID-19, the illness caused by infection with the novel coronavirus SARS-CoV-2, is a rapidly spreading global pandemic in urgent need of effective treatments. Here we present a comprehensive examination of the host- and virus-targeted functions of the flavonolignan silibinin, a potential drug candidate against COVID-19/SARS-CoV-2. As a direct inhibitor of STAT3-a master checkpoint regulator of inflammatory cytokine signaling and immune response-silibinin might be expected to phenotypically integrate the mechanisms of action of IL-6-targeted monoclonal antibodies and pan-JAK1/2 inhibitors to limit the cytokine storm and T-cell lymphopenia in the clinical setting of severe COVID-19. As a computationally predicted, remdesivir-like inhibitor of RNA-dependent RNA polymerase (RdRp)-the central component of the replication/transcription machinery of SARS-CoV-2-silibinin is expected to reduce viral load and impede delayed interferon responses. The dual ability of silibinin to target both the host cytokine storm and the virus replication machinery provides a strong rationale for the clinical testing of silibinin against the COVID-19 global public health emergency. A randomized, open-label, phase II multicentric clinical trial (SIL-COVI...Continue Reading

Associated Clinical Trials

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Citations

Dec 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohammed SikanderMeena Jaggi
Sep 16, 2020·European Journal of Pharmacology·Vivek Kumar SoniNaveen Kumar Vishvakarma
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Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sajad FakhriJavier Echeverría
Aug 8, 2021·International Journal of Molecular Sciences·Vladimír Křen

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Clinical Trials Mentioned

NCT04321993
NCT04320277

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