Silibinin prevents depression-like behaviors in a single prolonged stress rat model: the possible role of serotonin

BMC Complementary Medicine and Therapies
Bombi LeeBongjun Sur

Abstract

Post-traumatic stress disorder (PTSD) is an extreme mood disorder that occurs after experiencing extreme stress, and patients with this disorder are known to accompany with symptoms of depression, anxiety, and memory impairments. Silibinin (SIL) is a natural polyphenolic flavonoid and is the main active ingredient of silymarin, which is primarily extracted from the milk thistle. Although some studies have assessed the properties of this flavonoid, the potential of SIL as a treatment for PTSD patients and its mechanisms of action have yet to be fully elucidated. After exposure to a model of single prolonged stress (SPS), the open field test (OFT) and forced swimming test (FST), were used to investigate the effects of SIL on anxiety- and depression-like symptoms in male rats. The rats received of SIL (25, 50, and 100 mg/kg) for 14 days following exposure to SPS. Administration of SIL significantly improved anxiety-like behaviors in the OFT, depression-like behaviors in the FST, and freezing behavior in fear conditioning test. SIL also increased levels of serotonin in the hippocampus (Hipp) and amygdala, and enhanced expression of tryptophan hydroxylase-1 mRNA in the Hipp. The administration of SIL also inhibited SPS-induced decre...Continue Reading

References

Feb 15, 1978·European Journal of Pharmacology·R D PorsoltM Jalfre
Mar 29, 1997·Lancet·K A SmithP J Cowen
May 30, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A A HarrisonA Markou
Aug 2, 2001·The American Journal of Psychiatry·T D GeraciotiJ W Kasckow
Jan 30, 2002·Depression and Anxiety·Rodrigo EscalonaJonathan R T Davidson
Jul 13, 2004·Science·Xiaodong ZhangMarc G Caron
Dec 11, 2007·Pharmacology, Biochemistry, and Behavior·Katsuya HaradaNobuya Matsuoka
May 13, 2008·Cancer Letters·Kumaraguruparan Ramasamy, Rajesh Agarwal
Oct 17, 2008·Nature·Vaishnav Krishnan, Eric J Nestler
Nov 26, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sunoh KwonDae-Hyun Hahm
Aug 17, 2011·Pharmacology, Biochemistry, and Behavior·Malika El YacoubiJean-Marie Vaugeois
Feb 14, 2012·The Journal of Pain : Official Journal of the American Pain Society·Lorenzo Di Cesare MannelliCarla Ghelardini
Oct 11, 2012·Nature Reviews. Neuroscience·Roger K PitmanIsrael Liberzon
Dec 12, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·L I SerovaE L Sabban
Dec 19, 2013·Pharmacology, Biochemistry, and Behavior·Milind GeedSairam Krishnamurthy
Jan 15, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Huang NieQingrong Tan
Apr 3, 2014·Stress : the International Journal on the Biology of Stress·Sergio D IñiguezBrandon L Warren
Aug 6, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Chen-Cheng LinYia-Ping Liu
Dec 8, 2017·Journal of Psychopharmacology·Vishnu N ThakareBhoomika M Patel
Jan 1, 2019·PloS One·Debra A ValdiviesoTomás Eduardo Ceremuga

❮ Previous
Next ❯

Citations

Nov 24, 2020·Archives of Pharmacal Research·Yong-Hyun KoChoon-Gon Jang

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
electrophoresis
ELISA

Software Mentioned

MART Tracker
SPSS

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Related Papers

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
T J Colgan
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Katharina Esser-NobisVolker Lohmann
Cell Growth & Differentiation : the Molecular Biology Journal of the American Association for Cancer Research
S IzraeliI R Kirsch
Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
H WeissM Weiss
© 2021 Meta ULC. All rights reserved