Silica-Calix Hybrid Composite of Allyl Calix[4]arene Covalently Linked to MCM-41 Nanoparticles for Sustained Release of Doxorubicin into Cancer Cells

ACS Omega
Nilesh NarkhedeChebrolu Pulla Rao

Abstract

An inorganic-organic hybrid material, MCM-allylCalix, was synthesized by covalent modification of an MCM-41 surface with a tetra-allyl calixarene conjugate. The synthesized hybrid was characterized by 13C and 29Si MAS-NMR, Fourier transform infrared (FT-IR), Brunauer-Emmett-Teller surface area, thermogravimetric analysis (TGA), and transmission electron microscopy (TEM) analyses. The application of this MCM-allylCalix hybrid has been demonstrated for loading and in vitro release of doxorubicin (Dox) in phosphate-buffered saline (PBS) buffer as well as in the cancer cells, viz., MCF7, HeLa, and MDA-MB231. The Dox-loaded hybrid, MCM-allylCalix-Dox, was characterized by TEM, FT-IR, TGA, N2 sorption, diffuse refectance spectroscopy-UV, and fluorescence microscopy to confirm the presence of the drug. The release study of the drug from MCM-allylCalix-Dox was carried out in PBS buffer at pH 5 and 7.4. The results showed ∼140% increase in the release of Dox at pH 5 compared to that at pH 7.4 in 144 h, suggesting a pH-triggered release of the drug. MCM-allylCalix-Dox releases a greater amount of Dox compared to that released from unmodified MCM-Dox. Cytotoxicity studies suggested that MCM-allylCalix-Dox exhibits anticancer activity that...Continue Reading

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Citations

Mar 2, 2019·Drug and Chemical Toxicology·Virginia TzankovaBorislav Tzankov
May 28, 2019·Environmental Science and Pollution Research International·Muhammad SalmanFarrukh Mansoor
Dec 16, 2020·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Steffi TiburciusAjayan Vinu
Jul 30, 2020·Current Drug Delivery·Alejandro Ávila-OrtegaWilliam Alejandro Talavera-Pech
Jul 16, 2019·Chemical Reviews·Rajesh KumarJong Seung Kim
Aug 29, 2021·Pharmaceutics·José Antonio LebrónFrancisco J Ostos

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Methods Mentioned

BETA
transmission electron microscopy
fluorescence
fluorescence-activated cell sorting
fluorescence microscopy
FACS
X-ray

Software Mentioned

allylCalix
MCM

Related Concepts