PMID: 9635252Jun 23, 1998Paper

Silica deposition in the lung during epithelial injury potentiates fibrosis and increases particle translocation to lymph nodes

Experimental Lung Research
I Y Adamson, H Prieditis

Abstract

Increased respiratory disease and daily mortality rates are associated with higher levels of fine particulate air pollutants. We examined the possibility that deposition of particles to previously injured lungs might accentuate pulmonary damage, by investigating how the lung handled silica deposited during a phase of epithelial injury. A low dose of intratracheal (i.t.) bleomycin (BL) was used to induce epithelial damage in mice; 3 days later, 0.2 mg silica was instilled. Lung injury, measured by cell numbers and protein levels in bronchoalveolar lavage, was increased at 1 week and many silica particles translocated to the interstitium. At 12 weeks, the silica plus BL group showed increased pulmonary fibrosis biochemically and morphologically, and had significantly higher retained-silica content in the lung. In addition, these mice showed enlarged hilar lymph nodes with many granulomas-containing macrophages and silica. The results indicate that instillation of fine particulates to the alveoli at a time of epithelial damage potentiates the lung injury and increases translocation of particles to the interstitium. In the case of silica, deposition of particles into injured lungs resulted in increased fibrosis. The demonstration o...Continue Reading

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Citations

May 5, 1999·American Journal of Respiratory Cell and Molecular Biology·I Y AdamsonS G Bjarnason
Apr 9, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Devender S DhandaUday B Kompella
May 11, 2010·Free Radical Biology & Medicine·Corrine R Kliment, Tim D Oury
Jul 14, 2007·Virchows Archiv : an International Journal of Pathology·Ulrich F VogelBurkhard Bültmann
Jul 29, 2017·American Journal of Respiratory and Critical Care Medicine·Coralynn S SackJoel D Kaufman

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