Silica suppresses Toll-like receptor ligand-induced dendritic cell activation.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Celine A Beamer, Andrij Holian

Abstract

Inhalation of silica, without evidence of silicosis, is believed to predispose individuals to bacterial infections and impair respiratory immune functions. Silica may alter the sensitivity of antigen-presenting cells (APCs), such as macrophages and dendritic cells (DCs), to other types of infection; however, the exact nature of these exchanges remains uncertain. The purpose of the present study is to characterize the effect of silica exposure on innate pulmonary defense mechanisms following Toll-like receptor (TLR) ligand-induced activation using DCs as a model APC and determine whether these signals act in synergy or opposition to one another. Using C57Bl/6 mice, pattern recognition receptor expression on DCs was examined in vitro and in vivo using flow cytometry, and the activation state of pulmonary and granulocyte-macrophage colony-stimulating factor-derived DCs was assessed in response to silica in combination with TLR ligands (lipopolysaccharide, cytosine-phosphate-guanine, or polyinosinic:polycytidylic acid) using flow cytometry and measurement of cytokine production. In this study, silica attenuated TLR ligand-dependent DC activation with regards to accessory molecule expression as well as nitric oxide and inflammatory ...Continue Reading

References

Nov 1, 1982·Infection and Immunity·S N VogelA D O'Brien
Nov 1, 1994·American Journal of Respiratory and Critical Care Medicine·R L Cowie
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·P C HannaR J Collier
Jan 1, 1996·Annual Review of Immunology·D J LenschowJ A Bluestone
Oct 30, 1999·Immunology and Cell Biology·P A Stumbles
Aug 23, 2000·The Journal of Clinical Investigation·B N LambrechtR A Pauwels
Sep 29, 2001·Nature Immunology·C Bogdan
Jan 29, 2002·International Immunopharmacology·Min DingVal Vallyathan
Mar 23, 2002·Biochimica Et Biophysica Acta·Tsuneyasu Kaisho, Shizuo Akira
Apr 16, 2002·Science·Ruslan Medzhitov, Charles A Janeway
Jul 9, 2002·Clinical and Experimental Immunology·J W Coleman
Aug 16, 2003·American Journal of Respiratory Cell and Molecular Biology·Clinton S RobbinsMartin R Stämpfli
Aug 30, 2003·The European Respiratory Journal. Supplement·C Delclaux, E Azoulay
Sep 10, 2003·American Journal of Respiratory Cell and Molecular Biology·Kena A SwansonDavid S Wilkes
Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcello ChieppaPaola Allavena
Jul 9, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Johan ØvrevikMagne Refsnes
Oct 8, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kena A SwansonDavid S Wilkes
Dec 4, 2004·American Journal of Respiratory Cell and Molecular Biology·Ingel K DemedtsRomain A Pauwels
Dec 15, 2004·Microbes and Infection·Tsuneyasu Kaisho, Shizuo Akira
Apr 26, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Celine A Beamer, Andrij Holian
Jul 30, 2005·Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer·Jung-Kyoung ChoiYoung Lim
Sep 20, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Min DingVal Vallyathan
Dec 1, 2005·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Lucie McCoyPaul Simon
Mar 3, 2006·Immunology and Cell Biology·Maria TsoumakidouNikolaos M Siafakas
May 6, 2006·The Journal of Allergy and Clinical Immunology·Tsuneyasu Kaisho, Shizuo Akira
May 17, 2006·Veterinary Microbiology·Armin Saalmüller
Sep 21, 2006·The Journal of Biological Chemistry·Raymond F HamiltonAndrij Holian
Nov 30, 2006·Journal of Biomedical Materials Research. Part a·Meeyul HwangTae-Sung Lee
Jan 24, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ranmal SamarasingheKeiko Ozato
Feb 24, 2007·Nature Reviews. Immunology·Giorgio Trinchieri, Alan Sher
Mar 3, 2007·Annual Review of Biochemistry·Myeong Sup Lee, Young-Joon Kim

❮ Previous
Next ❯

Citations

Aug 22, 2013·Seminars in Immunopathology·Celine A Beamer, David M Shepherd
Jun 2, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Giulia GiordanoFrançois Huaux
Apr 6, 2013·BMC Medicine·Kenneth Michael Pollard, Dwight H Kono
Feb 26, 2016·Frontiers in Immunology·Gillian L BeamerCeline A Beamer
Jul 22, 2015·Inhalation Toxicology·Hajime Kawasaki
Oct 22, 2009·Antioxidants & Redox Signaling·Ming-Jie WangYi-Chun Zhu
Jan 29, 2019·Frontiers in Immunology·Petr KonečnýMuazzam Jacobs
Sep 16, 2020·International Journal of Molecular Sciences·Ho-Ryun WonBon Seok Koo
Mar 14, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fabrizio FazziLuis A Ortiz
Feb 19, 2021·Journal of Clinical Tuberculosis and Other Mycobacterial Diseases·Massimiliano Lanzafame, Sandro Vento

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.