Silicate antibodies in women with silicone breast implants: development of an assay for detection of humoral immunity.

Clinical and Diagnostic Laboratory Immunology
G Q ShenJ B Peter

Abstract

Silicon, in the form of sodium silicate (Na2SiO3), adsorbed onto bovine serum albumin (BSA)-precoated plates served as the solid-phase antigen in an enzyme immunoassay to detect silicate-reactive antibodies in the plasma of 40 symptomatic women with silicone breast implants, 91 asymptomatic women with silicone breast implants, 50 healthy control women, and 52 women with rheumatic diseases and without silicone breast implants, Silicate-reactive antibodies of immunoglobulin G (IgG) or IgM isotypes were detected in the plasma of 30% (12 of 40) of the symptomatic women with silicone breast implants; 9% (8 of 91) of the asymptomatic women with silicone breast implants; 5% (1 of 20) of the women without implants who had systemic lupus erythematosus; and 0% (0 of 32) of the women without implants who had either Sjögren syndrome, scleroderma, or rheumatoid arthritis. Only 2% (1 of 50) of the sera from the healthy control women contained silicate-reactive antibodies. Preincubation of sera with silicate and eight other metal compounds (including SiO2) demonstrated that the IgG and IgM antibodies bound specifically to silicate, because preincubation with Na2SiO3 inhibited more than 90% of the activity, whereas CrO3, Li2SO4, MgSO4, NiSO4, ...Continue Reading

References

May 1, 1992·Annals of Plastic Surgery·A R Shons, W Schubert
Sep 1, 1988·Arthritis and Rheumatism·M S AgopianJ B Peter
Sep 1, 1987·Journal of Biomedical Materials Research·N KossovskyM C Robson
Aug 12, 1983·Journal of Immunological Methods·R LindmarkJ Sjöquist
Jan 1, 1984·Reviews of Infectious Diseases·C A Dinarello
Jul 1, 1983·Annals of Plastic Surgery·J P HeggersT J Raine
Oct 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L E WolfE G Ezrailson
Nov 1, 1994·Clinical and Diagnostic Laboratory Immunology·E A Ojo-AmaizeJ B Peter

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