Silicon addition to hydroxyapatite increases nanoscale electrostatic, van der Waals, and adhesive interactions

Journal of Biomedical Materials Research. Part a
Jennifer VandiverChristine Ortiz

Abstract

The normal intersurface forces between nanosized probe tips functionalized with COO(-)-terminated alkanethiol self-assembling monolayers and dense, polycrystalline silicon-substituted synthetic hydroxyapatite (SiHA) and phase pure hydroxyapatite (HA) were measured via a nanomechanical technique called chemically specific high-resolution force spectroscopy. A significantly larger van der Waals interaction was observed for the SiHA compared to HA; Hamaker constants (A) were found to be A(SiHA) = 35 +/- 27 zJ and A(HA) = 13 +/- 12 zJ. Using the Derjaguin-Landau-Verwey-Overbeek approximation, which assumes linear additivity of the electrostatic double layer and van der Waals components, and the nonlinear Poisson-Boltzmann surface charge model for electrostatic double-layer forces, the surface charge per unit area, sigma (C/m(2)), was calculated as a function of position for specific nanosized areas within individual grains. SiHA was observed to be more negatively charged than HA with sigma(SiHA) = -0.024 +/- 0.013 C/m(2), two times greater than sigma(HA) = -0.011 +/- 0.006 C/m(2). Additionally, SiHA was found to have increased surface adhesion (0.7 +/- 0.3 nN) compared to HA (0.5 +/- 0.3 nN). The characterization of the nanoscale v...Continue Reading

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Citations

Apr 8, 2015·Journal of Biomedical Materials Research. Part a·Robert J FriederichsSerena M Best
Jan 22, 2010·Journal of Biomedical Materials Research. Part a·Elena LandiStefano Guizzardi
Dec 4, 2008·Journal of Biomedical Materials Research. Part a·Ping LiuWilliam Bonfield
Jun 5, 2015·Journal of the Royal Society, Interface·Robert J FriederichsSerena M Best
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Sudhanshu ShekharPrashant N Kumta
Jan 23, 2014·Biomedical Materials·Poon Nian LimEng San Thian
Sep 21, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Richard L WilliamsLiam M Grover
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Shunxiang XuKerong Dai
Jun 13, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Marité CárdenasThomas Arnebrant
Mar 28, 2008·The Journal of Physical Chemistry. B·Xiu-Li DongQi Wang
Jun 19, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Ariel R GuerreroMarcelo J Kogan
May 23, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Rodrigo GonzalezFrancisco Melo

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