Silicon metabolism. II. Renal handling in chronic renal failure patients

Nephron
A J Adler, G M Berlyne

Abstract

In 36 patients suffering from chronic renal failure (mean creatinine clearance 26 ml/min), serum silicon levels were significantly increased (mean 0.52 microgram/ml compared with 0.265 microgram/ml in normals; p less than 0.005). Urinary silicon excretion per 24 h was significantly decreased (15.71 mg/24 h compared with 21.4 mg/24 h in normals; p less than 0.001). Fractional excretion of silicon (FESi) was significantly increased in chronic renal failure (p less than 0.001), with overall tubular secretion of silicon in 33% of patients. Urinary excretion of silicon was significantly related to urinary calcium excretion (p less than 0.0001) urinary magnesium excretion (p less than 0.0001) creatinine clearance (p less than 0.05) and sodium excretion (p less than 0.05). It is suggested that urinary silicon is in the form of orthosilicate, principally bound to calcium and magnesium; and that in chronic renal failure the increase in FESi, and the decrease in absorbed Si from the gastrointestinal tract, moderate the increase in plasma silicon levels and prevent excessive entry of silicon into the tissues.

Citations

Jan 1, 1990·International Urology and Nephrology·S Hosokawa, O Yoshida
May 1, 1993·Biological Trace Element Research·J NajdaF Zych
Aug 1, 1989·Journal of the American College of Nutrition·R D Lindeman
Aug 21, 2010·Calcified Tissue International·Matthias WiensWerner E G Müller
Dec 1, 1986·The American Journal of Physiology·A J AdlerG M Berlyne
Nov 5, 2020·Veterinary Medicine International·Claudia Iveth Mendoza-LópezMarco Antonio Barbosa-Mireles
Oct 1, 1992·Kidney International·H J GitelmanS J Perry

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