Silicon substrate effects on ionic current blockade in solid-state nanopores

Nanoscale
Makusu TsutsuiTomoji Kawai

Abstract

We investigated the roles of silicon substrate material compositions in ionic current blockade in solid-state nanopores. When detecting single nanoparticles using an ionic current in a Si3N4 nanopore supported on a doped silicon wafer, resistive pulses were found to be blunted significantly via signal retardation due to predominant contributions of large capacitance at the ultrathin membrane. Unexpectedly, in contrast, changing the substrate material to non-doped silicon led to the sharpening of the spike-like signal feature, suggesting a better temporal resolution of the cross-channel ionic current measurements by virtue of the thick intrinsic semiconductor layer that served to diminish the net chip capacitance. The present results suggest the importance of the choice of Si compositions regarding the capacitance effects to attain better spatiotemporal resolution in solid-state nanopore sensors.

References

Jul 23, 2004·The Journal of Chemical Physics·C Y Kong, M Muthukumar
May 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Joseph W F RobertsonJohn J Kasianowicz
Jul 26, 2008·Nature Nanotechnology·Cees Dekker
Jul 23, 2009·Chemical Society Reviews·Stefan Howorka, Zuzanna Siwy
Jul 7, 2011·Nanotechnology·Stefan W KowalczykCees Dekker
Oct 20, 2011·Nature Communications·Weihua GuanMark A Reed
Mar 20, 2012·ACS Nano·Makusu TsutsuiTomoji Kawai
Jul 12, 2012·Nano Letters·David B WellsAleksei Aksimentiev
Nov 20, 2012·Chemical Reviews·Joseph E ReinerJohn J Kasianowicz
Jun 5, 2014·Annual Review of Analytical Chemistry·Long LuoHenry S White
Dec 17, 2014·Scientific Reports·Min-Hyun LeeKi-Bum Kim
Dec 5, 2015·Scientific Reports·Kazuma MatsuiKen-ichi Takeda
Oct 18, 2016·Advanced Functional Materials·James WilsonAleksei Aksimentiev
Dec 20, 2016·Nature Nanotechnology·Erik C YuskoMichael Mayer
Sep 8, 2017·Journal of the American Chemical Society·Hirotoshi YasakiYoshinobu Baba
Dec 14, 2017·Scientific Reports·Makusu TsutsuiTomoji Kawai
Sep 12, 2018·ACS Applied Materials & Interfaces·Makusu TsutsuiTomoji Kawai
Nov 27, 2018·Journal of the American Chemical Society·Akihide ArimaTomoji Kawai

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Citations

Nov 4, 2020·Physical Chemistry Chemical Physics : PCCP·Mostafa BakoueiMojtaba Taghipoor
Aug 29, 2019·ACS Omega·Iat Wai LeongTomoji Kawai

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Methods Mentioned

BETA
electron-beam lithography
electrophoretic
electrophoretic translocation
chips
electron microscopy
chip

Software Mentioned

LabVIEW

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