PMID: 8614251Mar 10, 1995Paper

Silicone breast implants: immunotoxic and epidemiologic issues

Life Sciences
S H YoshidaM E Gershwin

Abstract

Silicone gel implants for breast augmentation and reconstruction have been in use since 1962. Significant local complications include capsular contracture, rupture, gel "bleed", and spread of the implant material to regional lymph nodes (1-7) as well as histologic findings of foreign body granulomas in the capsular tissue and in lymph nodes (7-9). Through magnetic resonance spectroscopy and atomic emission spectroscopy, silicon compounds were found in the blood of some women with silicone breast implants; silicone and silica have also been found in liver (10). Well-publicized case reports have raised significant concerns regarding an association between implants and systemic disease. However, despite the availability of silicone implants for over 30 years, controlled epidemiological studies were not carried out until 1992. Currently available epidemiologic data are extremely limited. In part, because the majority of implants were used after 1981, the incidence of long-term problems is not yet known. In 1992, due to the unavailability of studies demonstrating the safety of implants, the U.S. Food and Drug Administration advised that silicone breast implants should be used only in reconstructive surgery and as part of clinical tr...Continue Reading

References

May 1, 1979·Arthritis and Rheumatism·Y KumagaiY Shiokawa
Jan 27, 1978·Science·M G WickhamJ L Abraham
Dec 1, 1976·Plastic and Reconstructive Surgery·E Domanskis, J Q Owsley
Jun 1, 1977·Plastic and Reconstructive Surgery·M C FelibertiG A Colon
Dec 1, 1977·Plastic and Reconstructive Surgery·I K CohenS D Theogaraj
Jun 18, 1992·The New England Journal of Medicine·D A Kessler
Mar 1, 1992·Plastic and Reconstructive Surgery·A F MarquesJ M Andrews
Nov 1, 1990·The Journal of Clinical Endocrinology and Metabolism·A W KungC L Lai
Dec 1, 1990·Plastic and Reconstructive Surgery·S K BrantleyS K Das
Sep 1, 1989·Annals of Internal Medicine·J VargaS A Jimenez
Mar 1, 1967·Plastic and Reconstructive Surgery·J E HoopesW Shelley
Dec 1, 1968·Plastic and Reconstructive Surgery·J S Nosanchuk
Apr 1, 1967·Plastic and Reconstructive Surgery·T D ReesG A Hawthorne
Jun 1, 1982·Arthritis and Rheumatism·S A van NunenA Basten
Jul 1, 1980·Plastic and Reconstructive Surgery·G D Nelson
Jul 20, 1994·Journal of the National Cancer Institute·M PotterF W Miller
Mar 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L GarridoD B Kopans
Apr 1, 1994·Plastic and Reconstructive Surgery·K E WellsS E Albers
Jun 16, 1994·The New England Journal of Medicine·S E GabrielL J Melton
Nov 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B PfleidererL Garrido
Dec 1, 1993·British Journal of Urology·P A Anderson, A H Travers
Jun 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L GarridoJ L Ackerman
Mar 1, 1993·Journal of Biomedical Materials Research·K FujimotoY Ikada
Aug 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B PfleidererL Garrido
Feb 1, 1993·The Journal of Cell Biology·R L Juliano, S Haskill
Jun 1, 1993·Plastic and Reconstructive Surgery·C Lossing, H A Hansson
Mar 1, 1993·Immunological Investigations·J O NaimC J van Oss
May 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B PfleidererL Garrido
Jun 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·B PERNIS, F PARONETTO
Nov 1, 1947·Annals of Surgery·B EisemanN A Womack

❮ Previous
Next ❯

Citations

Oct 1, 1996·Arthritis and Rheumatism·D M Marcus
Jun 7, 2003·British Journal of Plastic Surgery·Adam ToppingGeoffrey Wilson
Jun 1, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Imke BernerBettina Pfleiderer
Apr 18, 2001·Annals of Epidemiology·L A BrintonR N Hoover
Jan 29, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anja C RodenAhmet Dogan
Dec 13, 2003·Tissue Engineering·Joerg BorgesG Björn Stark
Oct 6, 1997·Journal of the National Cancer Institute·L A Brinton, S L Brown
Dec 27, 2007·Plastic and Reconstructive Surgery·Louise A Brinton
Jun 1, 2014·Archives of Pathology & Laboratory Medicine·Jie Xu, Shi Wei
Dec 6, 2014·Mutation Research. Reviews in Mutation Research·Xuan YeIain S Whitaker
Sep 27, 2015·Clinics in Plastic Surgery·Mark W Clemens, Roberto N Miranda
Dec 29, 2005·International Journal of Cancer. Journal International Du Cancer·Jacques BrissonYang Mao
Sep 13, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Andrés E QuesadaRoberto N Miranda
May 23, 2020·Plastic and Reconstructive Surgery. Global Open·Mark LeeSmathi Chong
Oct 16, 2020·Biomolecules·Vânia BorbaYehuda Shoenfeld
Apr 3, 2021·Journal of Autoimmunity·Gilad HalpertYehuda Shoenfeld
Mar 16, 2007·Journal of Autoimmunity·Roman Rieger, M Eric Gershwin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.