PMID: 8583725Nov 1, 1995Paper

Silicosis associated with autoimmune hemolytic anemia

Nihon Kyōbu Shikkan Gakkai zasshi
K SunamiM Ugaki

Abstract

A 60-year-old man with pneumoconiosis complained of general fatigue, exertional dyspnea, and anorexia. The patient had severe anemia, and laboratory examination revealed autoimmune hemolytic anemia with positive direct and indirect Coombs tests. After corticosteroid therapy, the anemia resolved markedly, and the antinuclear antibody test became negative. However, the silicotic shadow on chest X-ray film showed no remarkable change. The autoimmune hemolytic anemia in this case was probably due to an immunological disturbance caused by silicosis.

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