Silk fibroin nanoparticles support in vitro sustained antibiotic release and osteogenesis on titanium surface

Nanomedicine : Nanotechnology, Biology, and Medicine
Shaily SharmaS C Kundu

Abstract

Increasing amounts of metal-based implants are used for orthopedic or dental surgeries throughout the world. Still several implant-related problems such as inflammation, loosening and bacterial infection are prevalent. These problems stem from the immediate microbial contamination and failure of initial osteoblast adhesion. Additionally, bacterial infections can cause serious and life-threatening conditions such as osteomyelitis. Here, antibiotic (gentamicin)-loaded silk protein fibroin (non-mulberry silkworm, Antheraea mylitta) nanoparticles are fabricated and deposited over the titanium surface to achieve sustained drug release in vitro and to alter the surface nano-roughness. Based on the altered surface topography, chemistry and antibacterial activity, we conclude that the nanoparticle-deposited surfaces are superior for osteoblast adhesion, proliferation and differentiation in comparison to bare Ti. This method can be utilized as a cost-effective approach in implant modification. Titanium-based implants are commonly used in the field of orthopedics or dentistry. Surface modification of an implant is vital to ensure osseointegration. In this article, the author investigated the use of silk protein fibroins for metal surface...Continue Reading

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Citations

Sep 23, 2016·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Munish SharmaHeather Gappa-Fahlenkamp
Dec 6, 2016·International Journal of Molecular Sciences·Juan WangShenzhou Lu
Sep 11, 2018·Stomatologii︠a︡·I V MaiborodinA I Shevela
Sep 23, 2020·Journal of Materials Science. Materials in Medicine·Rosiana Boniatti CasagrandeCélia de Fraga Malfatti
Nov 23, 2016·BioMed Research International·Mohankandhasamy Ramasamy, Jintae Lee
Apr 19, 2017·FEMS Microbiology Reviews·Michal Natan, Ehud Banin
Nov 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ionut-Cristian RaduBianca Galateanu
Aug 5, 2017·Materials·Dave JaoXiao Hu
Jun 13, 2021·Macromolecular Bioscience·Zhaozhao DingQiang Lu
Dec 10, 2018·ACS Biomaterials Science & Engineering·Annish JainSonia Kapoor
May 13, 2019·ACS Biomaterials Science & Engineering·Shreya MehrotraBiman B Mandal
Aug 25, 2021·Biomedical Materials·Deboki NaskarSubhas C Kundu
Nov 11, 2021·Drug Delivery·Reem Khaled WassifSeham A Elkheshen

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