Silk fibroin protein-based nonwoven mats incorporating baicalein Chinese herbal extract: preparation, characterizations, and in vivo evaluation

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Wing P ChanMeng-Yi Bai

Abstract

In this study, we demonstrated a natural silk fibroin protein (SFP) that was blended with a Chinese herbal extract (baicalein, BAI) to obtain an effective combination for producing electrospun nonwoven mats with anti-inflammatory and antibacterial functions. A series of SFP-based electrospun nonwoven mats with additives of varying compositions were produced and investigated. Performance comparisons showed that the SFP/polyvinylpyrrolidone (PVP)/BAI nonwoven mat is the optimal one. In vitro, SFP/PVP/BAI nonwoven mat is effective in inhibiting the formation of nitrite in lipopolysaccharide (LPS)-induced nitrite formation in Raw 264.7 macrophages model and the growth of Staphylococcus aureus (S. aureus). Especially in the case of SFP/PVP/BAI nonwoven mat, Bai has been proved to reach their maximum amount of releases of approximately 64.8% within 24 h of contact with water-based environment as compared to the SFP/BAI nonwoven mat (only 30.1% of release within 24 h). For in vivo experiments, a 1.2 cm × 1.2 cm wound area was created on the back of mice and seeded with 1 × 107 CFU/mL of S. aureus to induce an infected wound model. The experimental results show significant acceleration of the wound closure process in mice treated with ...Continue Reading

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Citations

Mar 25, 2017·Nanomaterials·Wanwei ZhangElisa Mele
Jul 6, 2018·Membranes·Mandana AkiaKaren Lozano
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Ana Elisa Antunes Dos SantosRoberta Viana Ferreira
Feb 11, 2021·Pharmaceutics·Umile Gianfranco SpizzirriDonatella Restuccia

Related Concepts

Baicalein
RAW 264.7 Cells
Metazoa
Plant Extracts, Chinese
Fibroins, Spider
Macrophage
Periston
Staphylococcal Infections
Staphylococcus aureus
Wound Infection

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