Silk nanospheres and microspheres from silk/pva blend films for drug delivery.

Biomaterials
Xiaoqin WangDavid L Kaplan

Abstract

Silk fibroin protein-based micro- and nanospheres provide new options for drug delivery due to their biocompatibility, biodegradability and their tunable drug loading and release properties. In the present study, we report a new aqueous-based preparation method for silk spheres with controllable sphere size and shape. The preparation was based on phase separation between silk fibroin and polyvinyl alcohol (PVA) at a weight ratio of 1/1 and 1/4. Water-insoluble silk spheres were easily obtained from the blend in a three step process: (1) air-drying the blend solution into a film, (2) film dissolution in water and (3) removal of residual PVA by subsequent centrifugation. In both cases, the spheres had approximately 30% beta-sheet content and less than 5% residual PVA. Spindle-shaped silk particles, as opposed to the spherical particles formed above, were obtained by stretching the blend films before dissolving in water. Compared to the 1/1 ratio sample, the silk spheres prepared from the 1/4 ratio sample showed a more homogeneous size distribution ranging from 300 nm up to 20 microm. Further studies showed that sphere size and polydispersity could be controlled either by changing the concentration of silk and PVA or by applying u...Continue Reading

References

Nov 15, 2000·Journal of Biomedical Materials Research·S SofiaD L Kaplan
Nov 9, 2002·Biomaterials·Gregory H AltmanDavid L Kaplan
Jul 10, 2003·Journal of Microencapsulation·K E LeeS H Yuk
Dec 9, 2003·Journal of Molecular Biology·Elisabetta BiniDavid L Kaplan
Dec 29, 2004·Biomaterials·Rebecca L HoranGregory H Altman
Jul 6, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Oguz BayraktarAyşegül Batigün
Feb 7, 2006·Biomaterials·Chunmei LiDavid L Kaplan
Feb 7, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·S HofmannL Meinel
Jun 10, 2006·Advanced Drug Delivery Reviews·Jiyoung M Dang, Kam W Leong
Jan 16, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiaoqin WangDavid L Kaplan
Jun 5, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Julie A ChampionSamir Mitragotri
Jun 23, 2007·Biomaterials·Xiaoqin WangDavid L Kaplan
Jul 14, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xianyan WangDavid L Kaplan
Jul 24, 2007·Biomaterials·Lorenz UebersaxLorenz Meinel
Aug 28, 2007·International Journal of Nanomedicine·Andrea S GobinAnshu B Mathur
Nov 23, 2007·Biomaterials·Xiaoqin WangDavid L Kaplan
Dec 18, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Raghavendra C MundargiTejraj M Aminabhavi
Feb 19, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lorenz UebersaxLorenz Meinel
May 31, 2008·Nanomedicine·Federica ChielliniEmo Chiellini
Jun 3, 2008·Biomaterials·Andrew WilzDetlev Boison
Jun 6, 2008·Expert Opinion on Drug Delivery·Erik RyttingThomas Kissel
Sep 2, 2008·Nature Reviews. Drug Discovery·Mark E DavisDong M Shin
Sep 2, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Esther WenkLorenz Meinel
Dec 17, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiaoqin WangDavid L Kaplan
Jun 12, 2009·International Journal of Nanomedicine·Vishal GuptaAnshu B Mathur
Jul 7, 2009·Biomaterials·Keiji NumataDavid L Kaplan

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Citations

Jun 13, 2013·Acta Biomaterialia·Sangram K SamalEmo Chiellini
Jul 9, 2013·International Journal of Biological Macromolecules·Qin LuoYucheng Zhou
Jul 4, 2012·Biomacromolecules·Rangam RajkhowaXungai Wang
Oct 1, 2011·Nature Protocols·Danielle N RockwoodDavid L Kaplan
Oct 13, 2012·The Journal of Knee Surgery·Grace D O'ConnellClark T Hung
Jul 29, 2010·Nanomedicine·Anshu B Mathur, Vishal Gupta
Jan 15, 2014·International Journal of Biological Macromolecules·Li ChenHua Tong
Oct 15, 2013·Acta Biomaterialia·Jennifer E GagnerElliot L Chaikof
Nov 10, 2012·Advanced Drug Delivery Reviews·Banani KunduXungai Wang
Jul 27, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Mao YeGargi Ghosh
Oct 5, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Mao YeGargi Ghosh
Mar 10, 2015·International Journal of Molecular Sciences·Zheng ZhaoMao-Bin Xie
Apr 2, 2011·Expert Opinion on Drug Delivery·Eleanor M Pritchard, David L Kaplan
Dec 20, 2014·Expert Opinion on Drug Delivery·Sally Yunsun KimHak-Kim Chan
Jun 10, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tuna YucelDavid L Kaplan
Apr 24, 2012·Advanced Drug Delivery Reviews·Lorenz Meinel, David L Kaplan
May 9, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ahmed O ElzoghbyNazik A Elgindy
Sep 17, 2011·International Journal of Pharmaceutics·Pujiang Shi, James C H Goh
Dec 3, 2011·Journal of Membrane Science·Kiran A KarveDavid L Kaplan
Aug 9, 2011·Journal of Colloid and Interface Science·Guangfu YinJianwen Gu
Feb 25, 2011·Acta Biomaterialia·Qiang LuDavid L Kaplan
Aug 3, 2010·Biomaterials·Xiao HuDavid L Kaplan
Mar 20, 2010·Advanced Drug Delivery Reviews·Keiji Numata, David L Kaplan
Aug 1, 2015·International Journal of Biological Macromolecules·Nandana BhardwajDipali Devi
Jan 29, 2016·Biomedical Optics Express·Asma KhalidFiorenzo G Omenetto
Dec 15, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Yas Maghdouri-WhiteDidier Dréau
Dec 8, 2015·Microscopy Research and Technique·Qiang LiuYubo Fan
Sep 26, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Adrian B LiDavid L Kaplan
Oct 29, 2015·Nanoscale·Pallab SanpuiArun Chattopadhyay
Sep 13, 2015·Applied Microbiology and Biotechnology·Elena DoblhoferThomas Scheibel
Feb 22, 2011·Advanced Functional Materials·Tuna YucelDavid L Kaplan
Oct 25, 2011·Journal of Biomedical Materials Research. Part a·Mengjie ChenXin Chen
May 4, 2012·Advanced Materials·Hu TaoFiorenzo G Omenetto
Jul 25, 2013·Macromolecular Bioscience·John G HardyThomas R Scheibel
Sep 9, 2010·Macromolecular Bioscience·Xiaoqin Wang, David L Kaplan
Dec 18, 2013·Advanced Materials·Alexander N MitropoulosFiorenzo G Omenetto

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