Silk sericin protein of tropical tasar silkworm inhibits UVB-induced apoptosis in human skin keratinocytes.

Molecular and Cellular Biochemistry
Rupesh DashS C Kundu

Abstract

The silk protein sericin has been identified as a potent antioxidant and photoprotective agent against ultraviolet B (UVB) irradiation in mouse skin model. In this study, we have investigated the anti-apoptotic effect of sericin in UVB (30 mJ/cm2)-irradiated human keratinocytes. Flow cytometry analysis has shown that pre-treatment with sericin inhibits UVB-induced apoptosis. The pre-treatment with sericin suppresses bax expression, up-regulates the expression of bcl-2, prevents both the activation of caspase-3 and cleavage of Poly (ADP-ribose) polymerase. Generation of intracellular hydrogen peroxide in UVB-treated keratinocytes is inhibited through pre-treatment with sericin suggesting that sericin probably prevents mitochondrial damage.

References

Feb 7, 1997·Cell·M D JacobsonM C Raff
Apr 16, 1997·Journal of the National Cancer Institute·S K KatiyarR Agarwal
Nov 14, 1997·The New England Journal of Medicine·G J FisherJ J Voorhees
Mar 21, 1998·Bioscience, Biotechnology, and Biochemistry·N KatoM Nomura
Oct 28, 1999·The Journal of Investigative Dermatology. Symposium Proceedings·S Beissert, T Schwarz
Sep 21, 2000·The Journal of Investigative Dermatology·C Petit-FrèreC F Arlett
Nov 15, 2000·Journal of Biomedical Materials Research·S SofiaD L Kaplan
Jul 12, 2002·Molecular Carcinogenesis·Samar MaaloufHala Gali-Muhtasib
Sep 6, 2002·Biochemical Pharmacology·Dagmar Kulms, Thomas Schwarz
Feb 25, 2003·Bioscience, Biotechnology, and Biochemistry·Yoko TakasuKozo Tsubouchi
Mar 12, 2004·Chemico-biological Interactions·Chun Bo WangYue Jun Wang
Sep 25, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·An Van LaethemPatrizia Agostinis
May 18, 2005·Cancer Letters·Gautam BanerjeeGovindarajan Raman
Aug 16, 2005·The Journal of Investigative Dermatology·Mi Hee ShinJin Ho Chung
Feb 14, 2006·Journal of Bioscience and Bioengineering·Satoshi TeradaHideyuki Yamada
Feb 3, 2007·Toxicology Letters·Neelima Pathak, Shashi Khandelwal
Mar 14, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Rupesh DashS C Kundu

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Citations

Mar 2, 2019·International Journal of Molecular Sciences·Laura Rojas LorzJae Youl Cho
Mar 21, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Jadi Praveen Kumar, Biman B Mandal
Aug 23, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Jadi Praveen Kumar, Biman B Mandal
Mar 3, 2020·Journal of Basic Microbiology·Hafiz Muhammad TahirGhulam Murtaza
Jun 23, 2015·Macromolecular Bioscience·Khoon S LimPenny J Martens
Jan 14, 2012·Biopolymers·S C KunduAnanta K Ghosh
Sep 18, 2020·Advanced Healthcare Materials·Yu SongLin Wang
Dec 7, 2013·ISRN Pharmacology·Amnart Onsa-ArdChainarong Tocharus
Jul 19, 2015·Acta Biochimica Et Biophysica Sinica·Xinyi HeXingmeng Lu
Sep 25, 2015·Bioscience, Biotechnology, and Biochemistry·Tippawan SiritientongPornanong Aramwit
Aug 16, 2016·BioMed Research International·Neety SahuSubhas C Kundu
Feb 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Linhao LiLi Yang
Apr 12, 2012·Macromolecular Bioscience·Khoon S LimPenny J Martens
Dec 15, 2016·BioMed Research International·Regina Inês KunzMaria Raquel Marçal Natali
Feb 26, 2010·Science and Technology of Advanced Materials·Sushmitha SundarSubhas C Kundu
Nov 3, 2010·BMC Genomics·Jin-Ye ZhangCheng Lu
Nov 5, 2010·Chemical & Pharmaceutical Bulletin·Ayumu NishidaHiroaki Okada
Jul 17, 2015·Advances in Skin & Wound Care·Pornanong AramwitTippawan Siritientong
Jan 12, 2013·Cells, Tissues, Organs·Pornanong AramwitJuthamas Ratanavaraporn
Jun 26, 2020·Food Science and Biotechnology·In-Bong SongJungkee Kwon
Apr 21, 2012·Pakistan Journal of Biological Sciences : PJBS·Idress Hamad Attitalla
Sep 4, 2015·The Journal of Experimental Biology·Sarah D StellwagenMary E Clouse
May 10, 2011·International Journal of Biological Macromolecules·Biman B MandalS C Kundu
Sep 5, 2013·Biomacromolecules·Jasjeet KaurXungai Wang
Nov 10, 2010·Journal of Agricultural and Food Chemistry·Nanteetip LimpeanchobManote Sutheerawattananonda
Aug 25, 2021·Biomedical Materials·Deboki NaskarSubhas C Kundu
Oct 5, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Yasin BagheriSoheila Montazersaheb
Jan 18, 2011·International Journal of Pharmaceutics·Ayumu NishidaHiroaki Okada

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