Silvalactam, a 24-membered macrolactam antibiotic produced by Streptomyces sp. Tü 6392*

The Journal of Antibiotics
Dirk SchulzRoderich D Süssmuth

Abstract

Streptomycetes were isolated out of a soil sample taken from the rhizosphere of a spruce stand and screened by HPLC-diode array analysis for the production of secondary metabolites. This led to the detection of silvalactam, a novel 24-membered macrolactam antibiotic in extracts of Streptomyces strain Tü 6392. The structure was determined by MS and NMR spectroscopy experiments. Silvalactam shows a potent antiproliferative activity against various cancerous and non-cancerous cell lines.

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Citations

Nov 15, 2012·The Journal of Antibiotics·Niko ManderscheidRoderich D Süssmuth
May 16, 2013·Journal of Chemical Ecology·Nadine HorlacherSilvia D Schrey
Feb 17, 2017·Organic Letters·Christine BeemelmannsJon Clardy
Jun 14, 2014·Natural Product Reports·Fumitaka KudoTadashi Eguchi
Feb 6, 2020·Natural Product Reports·Shinichi Nishimura, Nobuaki Matsumori
May 26, 2018·Chembiochem : a European Journal of Chemical Biology·Yee Hwee LimHuimin Zhao
Jan 8, 2020·Microbial Cell Factories·Wan Lin YeoFong T Wong
Jun 6, 2020·The Journal of Antibiotics·Akimasa MiyanagaTadashi Eguchi
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sebastián A CuestaEdgar A Márquez

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