PMID: 9429028Jan 16, 1998Paper

Silvazine (silver sulfadiazine and chlorhexidine) activity against 200 clinical isolates

Burns : Journal of the International Society for Burn Injuries
N GeorgeM Muller

Abstract

The study was undertaken to examine the in vitro efficacy of Silvazine against micro-organisms commonly found in burn wounds. Two hundred non-replicative sequential clinical isolates were collected over a 2-month period. These comprised 50 Staphylococcus aureus (methicillin sensitive), 50 Staphylococcus aureus (methicillin resistant), 50 coagulase negative staphylococci and 50 Pseudomonas aeruginosa. As there is no standard test method, the method chosen was a pour plate overlay of micro-organisms placed on a Mueller Hinton base containing duplicate wells of 0.1 ml Silvazine. Plates were incubated at 35 degrees C for up to 48 h prior to examination. All organisms tested showed zones of growth inhibition. The mean diameters of the zones of growth inhibition were similar within genera. S. aureus 19.7 +/- 1.6 mm, MRSA 16.9 +/- 1.6 mm, P.aeruginosa 15.3 +/- 1.1 mm and coagulase negative staphylococci 20.8 +/- 2.1 mm. There was no bacterial regrowth within the zones of growth inhibition following long-term plate storage. In vitro testing of Silvazine has confirmed its efficiency against common burn wound isolates.

Citations

Jun 9, 2006·Journal of Industrial Microbiology & Biotechnology·Simon SilverGregg Silver
Mar 6, 2012·Journal of Materials Science. Materials in Medicine·Jennifer H ShepherdSerena M Best
Dec 25, 2003·Burns : Journal of the International Society for Burn Injuries·Edward E TredgetSarvesh Logsetty
Apr 13, 2005·The Journal of Hospital Infection·S L PercivalD Russell
Aug 1, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·A MastrolorenzoC T Supuran
Jul 13, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Corrie L Gallant-BehmRobert E Burrell
May 23, 2002·Antimicrobial Agents and Chemotherapy·Maria BellantoneLarry L Hench
Aug 5, 2011·Journal of Nanobiotechnology·Humberto H LaraDinesh K Singh
Jun 18, 2014·Critical Reviews in Microbiology·Elham AbbasiMohammad Samiei
Jan 29, 2013·Colloids and Surfaces. B, Biointerfaces·Meghana RamaniEnrico Marsili
Jun 15, 2010·Burns : Journal of the International Society for Burn Injuries·Jessie S GlasserClinton K Murray
Oct 4, 2008·International Journal of Pharmaceutics·Simon GaisfordDavid Parsons
Apr 15, 2008·Dental Materials : Official Publication of the Academy of Dental Materials·A BalamuruganJ M F Ferreira
Jul 24, 2007·Burns : Journal of the International Society for Burn Injuries·Leila CuttleRoy M Kimble
Mar 5, 2004·ANZ Journal of Surgery·John F FraserRoy M Kimble
Jan 27, 2012·Journal of Applied Microbiology·O Torres-Urquidy, K Bright
Mar 28, 2007·International Journal of Surgery·Seyed V HosseiniHooman Yarmohammadi
Feb 11, 2015·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Prinessa Chellan, Peter J Sadler
May 4, 2011·Journal of Wound Care·J G ThomasS L Percival
Feb 4, 1999·Nature Medicine·A GuptaS Silver
Mar 23, 2019·Microscopy Research and Technique·Umit Erdem, Mustafa B Turkoz
Mar 6, 2007·Journal of Wound Care·A B G Landsdown, A Williams
Oct 6, 2007·The International Journal of Artificial Organs·Y QiuX Wen
Dec 3, 1998·Applied and Environmental Microbiology·A GuptaS Silver
Aug 18, 2009·Biomacromolecules·Jian WuPatrick T Mather
Dec 15, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Harpreet PangliAziz Ghahary

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.