Silver nanocolloids disrupt medaka embryogenesis through vital gene expressions

Environmental Science & Technology
Shosaku KashiwadaG Thomas Chandler

Abstract

Silver nanomaterials are the major components of healthcare products largely because of their antimicrobial effects. However, their unintended toxicity to biological organisms and its mechanism are not well understood. Using medaka fish embryo model, the toxic effects and corresponding mechanisms of silver nanocolloids (SNC, particle size 3.8 ± 1.0-diameter nm) were investigated. SNC caused morphological changes in embryos including cardiovascular malformations, ischemia, underdeveloped central nervous system and eyes, and kyphosis at exposures of 0.5 mg/L. Interestingly, SNC were observed inside the eggs at a level of 786.1 ± 32.5 pg/mg egg weight, and TEM analysis showed that SNC adhered to the surface and inside of the chorion. Meanwhile, medaka oligo DNA microarray and qRT-PCR were used for gene expression analysis in the embryos exposed to 0.05 mg/L SNC for 48 h. As a result, expressions of six of the oxidative stress-, embryogenesis- and morphogenesis-related genes, ctsL, tpm1, rbp, mt, atp2a1, and hox6b6, were affected by the SNC exposure, and these genes' involvement in those malformations was implied. Thus, SNC could potentially cause malformations in the cardiovascular and central nervous systems in developing medaka ...Continue Reading

References

Jul 1, 1996·Environmental Health Perspectives·S A VillalobosP Kelly
Oct 31, 2002·Development·Je-Hwang RyuJang-Soo Chun
Feb 1, 2003·Aquatic Toxicology·Miguel González-DoncelDavid E Hinton
Jun 19, 2004·Science·Robert F Service
Jun 24, 2004·Mechanisms of Development·Takashi Iwamatsu
Jan 18, 2005·Science·Brian R KeeganDeborah Yelon
Jan 25, 2005·Nature Medicine·Carmen UrbichStefanie Dimmeler
Apr 28, 2005·Journal of Nanoscience and Nanotechnology·C BakerS Ismat Shah
Feb 4, 2006·Science·Andre NelNing Li
Jul 5, 2006·Environmental Health Perspectives·Taisen IguchiYoshinao Katsu
Aug 18, 2006·The Journal of Physical Chemistry. B·Ales PanacekRadek Zboril
Aug 31, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Vincent EvertsWouter Beertsen
Nov 14, 2006·The Journal of Clinical Investigation·Koichiro KuwaharaEric N Olson
May 15, 2007·Nature·Linda Z Holland
Jun 8, 2007·Nature·Masahiro KasaharaYuji Kohara
Jul 17, 2007·American Journal of Physiology. Heart and Circulatory Physiology·M A Hassan TalukderJay L Zweier
Jan 16, 2008·Sub-cellular Biochemistry·A Hovnanian
Mar 11, 2008·Archives of Biochemistry and Biophysics·Francesca Di LevaErnesto Carafoli
May 24, 2008·Environmental Toxicology and Chemistry·Shosaku KashiwadaKoichi Goka
Jul 17, 2008·Environmental Monitoring and Assessment·E PadminiB Vijaya Geetha
Aug 12, 2008·Environmental Toxicology and Chemistry·Robert J GriffittDavid S Barber
Sep 12, 2008·The Science of the Total Environment·Marta FerreiraMaria Armanda Reis-Henriques
Dec 17, 2008·Environmental Toxicology and Chemistry·Twyla Michelle Blickley, Patricia McClellan-Green
Feb 6, 2009·Environmental Science & Technology·Enrique NavarroRenata Behra
Oct 1, 2005·Nanotechnology·Jose Ruben MoronesMiguel Jose Yacaman
Dec 3, 2010·Journal of Nanoscience and Nanotechnology·Wei BaiZhifang Chai
Dec 15, 2010·Cardiovascular Research·Mei SunPeter P Liu
Jun 25, 2008·Nanotechnology·P V AsharaniSuresh Valiyaveettil

❮ Previous
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Citations

Apr 4, 2013·Chemosphere·Andrey MassarskyThomas W Moon
Jan 11, 2014·Advances in Colloid and Interface Science·Virender K SharmaJorge L Gardea-Torresdey
Aug 29, 2013·BioMed Research International·Jae-Gu ChoPilje Kim
Feb 14, 2016·Environmental Science and Pollution Research International·Ashkan BananMohammad Ali Yazdani Sadati
Jun 13, 2015·Marine Environmental Research·Chiara GambardellaFrancesca Garaventa
Dec 3, 2014·Environmental Toxicology and Pharmacology·Andrey MassarskyThomas W Moon
Oct 30, 2014·Archives of Environmental Contamination and Toxicology·Masaki SakamotoShosaku Kashiwada
Dec 9, 2014·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·Josephine A BonventreStacey L Harper
Jun 29, 2016·Nanotoxicology·Olivia J OsborneCharles R Tyler
Aug 19, 2016·Journal of Applied Toxicology : JAT·Chisato KataokaShosaku Kashiwada
Mar 1, 2016·Environmental Toxicology and Chemistry·Jing HuaWillie J G M Peijnenburg
Jan 25, 2017·The Science of the Total Environment·Roberto Carlos Valerio-GarcíaFernando Martínez-Jerónimo
Mar 21, 2017·Nanotoxicology·Anita ColomboParide Mantecca
Jan 19, 2018·Scientific Reports·Risa HoriuchiNobumitsu Miyanishi
Mar 19, 2020·International Journal of Molecular Sciences·Liyuan QiangJinping Cheng
Oct 25, 2020·Environmental Toxicology·Tomomi MatsukuraShosaku Kashiwada
Dec 25, 2019·The Science of the Total Environment·Jin Wuk LeePilje Kim
Jun 14, 2021·Environmental Science and Pollution Research International·Risa HoriuchiNobumitsu Miyanishi
Feb 23, 2013·Analytical Chemistry·Melissa A Maurer-JonesChristy L Haynes
Aug 6, 2019·Environmental Science & Technology·Su-Juan YuJing-Fu Liu
Oct 27, 2021·Journal of the Royal Society, Interface·Sreyashi ChakrabortyPavlos P Vlachos
Nov 2, 2021·Journal of Toxicology and Environmental Health. Part a·Roland VogtDunja Katharina Lamatsch

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