Silver-nanoparticle-coated biliary stent inhibits bacterial adhesion in bacterial cholangitis in swine

Hepatobiliary & Pancreatic Diseases International : HBPD INT
Wei WenZhi-Ning Fan

Abstract

One of the major limitations of biliary stents is the stent occlusion, which is closely related to the over-growth of bacteria. This study aimed to evaluate the feasibility of a novel silver-nanoparticle-coated polyurethane (Ag/PU) stent in bacterial cholangitis model in swine. Ag/PU was designed by coating silver nanoparticles on polyurethane (PU) stent. Twenty-four healthy pigs with bacterial cholangitis using Ag/PU and PU stents were randomly divided into an Ag/PU stent group (n=12) and a PU stent group (n=12), respectively. The stents were inserted by standard endoscopic retrograde cholangiopancreatography. Laboratory assay was performed for white blood cell (WBC) count, alanine aminotransferase (ALT), interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) at baseline time, 8 hours, 1, 2, 3, and 7 days after stent placements. The segment of bile duct containing the stent was examined histologically ex vivo. Implanted biliary stents were examined by a scan electron microscope. The amount of silver release was also measured in vitro. The number of inflammatory cells and level of ALT, IL-1beta and TNF-alpha were significantly lower in the Ag/PU stent group than in the PU stent group. Hyperplasia of the mucosa wa...Continue Reading

Citations

Jun 6, 2020·Khirurgiia·A V ShabuninA A Karpov
May 27, 2020·Abdominal Radiology·Xin HeJunbo Hong
Aug 15, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiao-Yan XuYing-Bin Liu
Mar 16, 2021·Bio-medical Materials and Engineering·Akane YamabeMakoto Iijima
May 6, 2021·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Masaki KuwataniNaoya Sakamoto
Aug 17, 2021·Plastic and Reconstructive Surgery·Chandan K SenGayle M Gordillo

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