Silver nanoparticle synthesis in human ferritin by photochemical reduction.

Journal of Inorganic Biochemistry
Italo MogliaAlvaro Olivera-Nappa

Abstract

Ferritin is a globular hollow protein that acts as the major iron storage protein across living organisms. The 8 nm-diameter internal cavity of ferritin has been used as a nanoreactor for the synthesis of various metallic nanoparticles different to iron oxides. For this purpose, ferritin is incubated in solution with metallic ions that enter the cavity through its natural channels. Then, these ions are subjected to a reduction step to obtain highly monodisperse metallic nanoparticles, with enhanced stability and biocompatibility provided by the ferritin structure. Potential biomedical applications of ferritin-nanoparticle complex will require the use of human ferritin to provide a safer and low-risk alternative for the delivery of metallic nanoparticles into the body. However, most of the reported protocols for metallic nanoparticles synthesis uses horse spleen ferritin as nanocontainer. Previous studies have acknowledged technical difficulties with recombinant human ferritin during the synthesis of metallic nanoparticles, like protein precipitation, which is translated into low recovery yields. In this study, we tested a novel photochemical reduction method for silver nanoparticle synthesis in human recombinant ferritin and co...Continue Reading

References

Aug 28, 1989·FEBS Letters·D M LawsonP Arosio
Oct 14, 2004·Journal of the American Chemical Society·Ryan M KramerRajesh R Naik
Dec 21, 2006·Journal of the American Chemical Society·Masaki UchidaTrevor Douglas
Oct 29, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Masaki UchidaTrevor Douglas
Nov 11, 2008·Biochemistry·Christopher A ButtsIvan J Dmochowski
Jan 28, 2010·Journal of the American Chemical Society·Kevin G Stamplecoskie, Juan C Scaiano
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Li LiWilliam E Seaman
Dec 21, 2010·The Science of the Total Environment·Xingchen ZhaoXiaofang Liu
Feb 11, 2011·Angewandte Chemie·Xin LinXiaoyuan Chen
Jun 4, 2011·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Toshiro KitagawaMichael V McConnell
Jun 19, 2012·Nature Nanotechnology·Kelong FanXiyun Yan
May 21, 2014·Proceedings of the National Academy of Sciences of the United States of America·Rabindra K Behera, Elizabeth C Theil
Oct 1, 2014·Proceedings of the National Academy of Sciences of the United States of America·Minmin LiangXiyun Yan
Feb 17, 2015·Chemical Reviews·Günther JutzAlexander Böker
May 21, 2015·Journal of Biomedical Nanotechnology·Bharat BhushanP Gopinath
Feb 17, 2017·Proceedings of the National Academy of Sciences of the United States of America·Cecilia PozziPaola Turano
Mar 6, 2018·Frontiers of Chemical Science and Engineering·Zhantong WangXiaoyuan Chen

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