Silver nanoparticles as matrix for MALDI FTICR MS profiling and imaging of diverse lipids in brain

Talanta
Ming GuanZhenwen Zhao

Abstract

Owing to the diversity of lipids, profiling and imaging multiple classes of lipids in one analysis by matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI MSI) is a great challenge. In this work, polyvinylpyrrolidone (PVP) capped silver nanoparticles (AgNPs) was used as the matrix for MALDI MSI for the first time to simultaneously analyze 10 classes of lipids from the brain. This analysis included fatty acids and their derivatives, sterols, CPAs, LPA and PAs, LPE and PEs, LPC and PCs, PS, Cers, SMs, and MAGs and DAGs, and other small metabolites. Owing to the abundant silver ions on the surface of PVP-capped AgNPs, compounds with poor ionization efficiency such as FAs and sterols can be detected. The PVP-capped AgNPs based MALDI MSI analysis of mouse brain showed that lipid distributions in the substructures of the mouse brain can be connected with their biological functions. The brain lipids in rats with middle cerebral artery occlusion (MCAO) were also investigated. Most unsaturated FAs, prostaglandins, CPAs, vitamin A, neuraminic acid, 5-OH-tryptophan and the K+ adducts of most phospholipids (PAs, LPE, PEs, PCs, PS) and SMs were extremely down regulated in the ischemic region and saturated FA, Cers, h...Continue Reading

Citations

May 29, 2018·Journal of Neurochemistry·Mandana HunterMaurice A Curtis
Nov 6, 2018·The Journal of Comparative Neurology·Guang Xu, Jianjun Li
Aug 15, 2019·Journal of Mass Spectrometry : JMS·Ethan YangPierre Chaurand
Sep 10, 2018·Analytical and Bioanalytical Chemistry·Alireza BanazadehYehia Mechref
Oct 31, 2020·Analytical and Bioanalytical Chemistry·Wendy H MüllerGauthier Eppe
Nov 10, 2020·Mass Spectrometry Reviews·Kellen DeLaneyLingjun Li
Nov 12, 2020·Mass Spectrometry Reviews·Wendy H MüllerGauthier Eppe
Dec 20, 2020·Journal of Chromatography. a·Hua LiGuowang Xu
Jan 13, 2021·Mass Spectrometry Reviews·Carla HarkinDiego F Cobice
Dec 16, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Tara R HawkinsonRamon C Sun

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