Silver nanoparticles enhanced flow injection chemiluminescence determination of gatifloxacin in pharmaceutical formulation and spiked urine sample

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
S M WabaidurKazi Mohsin

Abstract

Silver nanoparticles have been utilized for the enhanced chemiluminogenic estimation of fluoroquinolone antibiotic gatifloxacin. It has been found that the weak chemiluminescence intensity produced from the reaction between calcein and KMnO4 can further be strengthened by the addition of silver nanoparticles in the presence of gatifloxacin. This phenomenon has been exploited to the quantitative determination of gatifloxacin. Under the optimum experimental conditions, the calibration curves are linear over the range of 8.9×10(-9)-4.0×10(-6) M, while the limits of detections were found to be 2.6×10(-9) M with correlation coefficient value (r(2)) 0.9999. The relative standard deviation calculated from six replicate measurements (1.0×10(-4) M gatifloxacin) was 1.70%. The method was applied to pharmaceutical preparations and the results obtained were in reasonable agreement with the amount labeled on the formulations. The proposed method was also used for the determination of gatifloxacin in spiked urine samples with satisfactory results. No interference effects from some common excipients used in pharmaceutical preparations have been found.

References

Dec 1, 1995·Antimicrobial Agents and Chemotherapy·M NakashimaH Uchida
Jan 2, 2009·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Changchuan GuoLihong Sang
Apr 10, 2012·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Saikh Mohammad WabaidurMu Naushad

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Citations

Aug 16, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hanna Leijoto de OliveiraKeyller Bastos Borges
May 27, 2021·Biosensors & Bioelectronics·Jun Jie OngAbdul W Basit

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