Silver nanoparticles functionalized Paclitaxel nanocrystals enhance overall anti-cancer effect on human cancer cells.

Nanotechnology
Nazim MuhammadHonglei Zhan

Abstract

For chemotherapeutic drugs, precise tumor-targeting and high anti-cancer efficiency is equally important in order to enhance chemotherapy and reverse drug resistance. The combination of multifunctional agents to achieve synergy should be a promising strategy. In our study, we have successfully developed novel multifunctionalized drug nanocrystals to realize co-delivery of the organic drug Paclitaxel (PTX), inorganic silver nanoparticles (AgNPs) and a tumor targeting agent. To be specific, PTX nanocrystals were first prepared as a template, then coated with polydopamine (PDA). The PDA layer was utilized as the connection bridge to produce and deposit AgNPs in situ, and provide sites for tumor-targeting peptide NR1 (RGDARF) grafting. As a result, these NR1/AgNP-decorated drug nanocrystals exhibited dramatically improved cellular uptake efficiency, in vitro anti-cancer activity and an anti-migratory effect against a variety of cancer cells, which was attributable to the synergistic, or at least additive, effect of the AgNPs and PTX, enhanced cellular uptake efficiency through NR1-receptor interaction, pH-responsive drug release and the nanoscaled nature. In particular, high anti-cancer activity and low side effects from these NR1/...Continue Reading

References

Feb 25, 2009·ACS Nano·P V AshaRaniSuresh Valiyaveettil
Nov 3, 2010·International Journal of Nanomedicine·Muthu Irulappan SriramSangiliyandi Gurunathan
Nov 15, 2011·Chemical Communications : Chem Comm·Lina MaoZhimou Yang
Sep 13, 2012·Molecular Pharmaceutics·Fabienne DanhierVéronique Préat
Jun 26, 2013·Journal of Materials Science. Materials in Medicine·Chia-Che Ho, Shinn-Jyh Ding
Aug 21, 2013·Biomaterials·Mengjiao ZhouXiaohong Zhang
Mar 7, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Xi ChenFrank Caruso
Jan 1, 2011·Cancer Nanotechnology·Deshpande RaghunandanA Venkataraman
Oct 3, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Mengjiao ZhouXiaohong Zhang
Oct 23, 2015·International Journal of Nanomedicine·Sangiliyandi GurunathanJin-Hoi Kim
Dec 15, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Dávid KovácsMónika Kiricsi
Jul 16, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wei GaoTonglei Li
Feb 6, 2017·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Honglei ZhanJun F Liang
Jul 25, 2017·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ganesh V Khutale, Alan Casey
Sep 5, 2017·Cancers·Markus NieberlerHorst Kessler
Sep 10, 2017·Cancer Chemotherapy and Pharmacology·C G Da SilvaLuis J Cruz
Jan 27, 2018·Cancer Biology & Medicine·Yan WenXingjie Liang
Oct 3, 2018·Materials Science & Engineering. C, Materials for Biological Applications·Elham AhmadianHale Ahmadian
Apr 28, 2019·Colloids and Surfaces. B, Biointerfaces·Jingwen ShiYu-Mei Shen
Nov 11, 2019·Journal of Photochemistry and Photobiology. B, Biology·Saritha ValsalamMariadhas Valan Arasu
Apr 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Honglei ZhanJun F Liang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis