PMID: 7516456Jun 1, 1994Paper

Silver stained nucleolar organizer region proteins and Helix pomatia agglutinin immunostaining in esophageal carcinoma: correlated prognostic factors

Journal of Surgical Oncology
Y YoshidaT Ezaki

Abstract

The number of nucleolar organizer region proteins identified by silver staining (AgNORs) and alterations in cell surface glycoproteins identified by Helix pomatia agglutinin (HPA) immunostaining were studied in 96 primary esophageal carcinomas. The number of AgNORs increased with increasing depth of cancer invasion, venous involvement, lymphatic invasion, and tumor stage. Positivity of HPA staining correlated significantly with increasing depth of cancer invasion, venous invasion, and tumor stage. Forty of 42 HPA negative cases had low AgNORs numbers (< 4), while 39 of 54 HPA positive cases had high AgNORs numbers (> or = 4) (P = 0.0001). The survival rate of patients with stage III and IV disease was significantly poorer for those with a high AgNORs score and HPA positivity than in those with a low AgNORs score and HPA negativity. The present study indicates that the AgNORs score is positively correlated with positive HPA staining and that tumors having both factors represent a subgroup of esophageal carcinomas with poor prognosis.

References

Jun 1, 1976·The Japanese Journal of Surgery· Japanese Society for Esophageal Diseases
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Jul 1, 1987·The Journal of Pathology·S FenlonR W Blamey
Oct 8, 1987·Nature·G Jordan

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Citations

Aug 1, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·R ChatterjeeR B Mitra
Jul 16, 1999·The American Journal of Gastroenterology·L S WangM H Huang
Aug 17, 2011·World Journal of Surgery·Rajeev ParameswaranSusan Brooks
Dec 1, 1996·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·D U SchumacherU Schumacher

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