Abstract
The aim of the present prospective, randomized, double-blind, and placebo-controlled investigation (approved by the Ethical Committee of Padova University Hospital [Italy]) was to assess the effect of a nasal gel containing a combination of silver sucrose octasulfate and potassium sucrose octasulfate (Silsos gel® [SG]) in wound healing after endoscopic sinus surgery (ESS) for chronic rhinosinusitis in terms of: nasal symptoms (SNOT22), endoscopic appearance of the sinonasal mucosa (Lund-Kennedy score), nasal air flow (anterior active rhinomanometry), evidence of mucosal inflammatory processes (nasal cytology and histology), and microbiological growth. Thirty-four patients with chronic rhinosinusitis were randomized on a 1:1 ratio to receive after ESS either SG or placebo (contained only the excipients [carbopol and propylene glycol] in the same concentrations as in SG). Judging from the present prospective investigation on patients who underwent ESS for chronic rhinosinusitis, treatment with SG seems to enable a significantly faster improvement in specific symptoms (assessed on the validated SNOT22 scale) than placebo. Patients treated with SG also had a quicker improvement in the endoscopic appearance of their nasal mucosa aft...Continue Reading
References
Mar 17, 1999·Plastic and Reconstructive Surgery·M A RashidT Taguchi
Sep 21, 2002·Molecular and Cellular Biology·Brian K YehMoosa Mohammadi
Jan 13, 2006·Histopathology·J B WateletC Bachert
Jul 5, 2008·American Journal of Otolaryngology·Alberto StaffieriGino Marioni
Oct 2, 2009·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·C HopkinsJ P Browne
Jun 12, 2010·American Journal of Otolaryngology·Giancarlo OttavianoAlberto Staffieri
Mar 3, 2011·Proceedings of the American Thoracic Society·Itzhak Brook
Apr 16, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·David DepoortereNoam A Cohen
May 29, 2013·American Journal of Rhinology & Allergy·Manuele CasaleSalvinelli Fabrizio
Jul 26, 2013·American Journal of Rhinology & Allergy·David DePoortereNoam A Cohen
Apr 29, 2014·American Journal of Otolaryngology·Vefa KınısIsmail Topcu
Jun 5, 2014·PloS One·Cinzia MarianelliGabriella Calderini
Jul 1, 2014·American Journal of Otolaryngology·Giancarlo OttavianoGino Marioni
Jul 1, 2014·The Laryngoscope·Gökçe ŞimşekAhmet Kizilay
Citations
Jun 2, 2016·Epidemiology and Infection·A Lovato, C DE Filippis
Oct 1, 2020·International Journal of Environmental Research and Public Health·Maria Angiola CrivellaroAndrea Trevisan
Apr 10, 2020·American Journal of Rhinology & Allergy·Giancarlo OttavianoAndrea Ermolao
Jan 17, 2020·International Journal of Molecular Sciences·Jegadevswari SelvarajahYogeswaran Lokanathan