Silver sucrose octasulfate nasal applications and wound healing after endoscopic sinus surgery: a prospective, randomized, double-blind, placebo-controlled study

American Journal of Otolaryngology
Giancarlo OttavianoAlberto Staffieri

Abstract

The aim of the present prospective, randomized, double-blind, and placebo-controlled investigation (approved by the Ethical Committee of Padova University Hospital [Italy]) was to assess the effect of a nasal gel containing a combination of silver sucrose octasulfate and potassium sucrose octasulfate (Silsos gel® [SG]) in wound healing after endoscopic sinus surgery (ESS) for chronic rhinosinusitis in terms of: nasal symptoms (SNOT22), endoscopic appearance of the sinonasal mucosa (Lund-Kennedy score), nasal air flow (anterior active rhinomanometry), evidence of mucosal inflammatory processes (nasal cytology and histology), and microbiological growth. Thirty-four patients with chronic rhinosinusitis were randomized on a 1:1 ratio to receive after ESS either SG or placebo (contained only the excipients [carbopol and propylene glycol] in the same concentrations as in SG). Judging from the present prospective investigation on patients who underwent ESS for chronic rhinosinusitis, treatment with SG seems to enable a significantly faster improvement in specific symptoms (assessed on the validated SNOT22 scale) than placebo. Patients treated with SG also had a quicker improvement in the endoscopic appearance of their nasal mucosa aft...Continue Reading

References

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Jul 1, 2014·American Journal of Otolaryngology·Giancarlo OttavianoGino Marioni

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Citations

Jun 2, 2016·Epidemiology and Infection·A Lovato, C DE Filippis
Oct 1, 2020·International Journal of Environmental Research and Public Health·Maria Angiola CrivellaroAndrea Trevisan
Apr 10, 2020·American Journal of Rhinology & Allergy·Giancarlo OttavianoAndrea Ermolao
Jan 17, 2020·International Journal of Molecular Sciences·Jegadevswari SelvarajahYogeswaran Lokanathan

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