Aug 21, 2010

Silver sulfadiazine for the treatment of partial-thickness burns and venous stasis ulcers

Journal of the American Academy of Dermatology
Andrew C MillerShahriar Zehtabchi

Abstract

For decades silver-containing antibiotics such as silver sulfadiazine (SSD) have been applied as standard topical therapy for patients with partial-thickness burns and venous stasis ulcers. This evidence-based review intends to answer the following research question: in ambulatory patients with partial-thickness burns or stasis dermatitis ulcers, does the use of topical SSD compared with nonantibiotic dressings improve mortality, wound healing, re-epithelialization, or infection rates? MEDLINE, EMBASE, Cochrane Library, and other databases were searched. We considered trials that enrolled patients of any age with partial-thickness burns or venous stasis ulcers and randomized them to either topical SSD or placebo, saline-soaked gauze, paraffin gauze, sterile dry dressing, or nonantibiotic moist dressing. Outcomes included mortality, wound healing, speed of re-epithelialization, and infection rates. For burns, our search revealed 400 potential articles. No human studies met the inclusion criteria. Only 7 animal studies (1 mouse, 4 rat, and 2 pig) were relevant to the proposed question. These animal studies provided conflicting results. Whereas some support the use of SSD for treatment of partial-thickness burns, others question i...Continue Reading

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  • Citations13
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Citations

Mentioned in this Paper

Septicemia
Isopropyl myristate
Dermazin
Re-Epithelialization
Sulfadiazine
Enzymes, antithrombotic
Venous Insufficiency
Antibiotic throat preparations
Propylene Glycol
Murine

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