Silybum marianum (milk thistle) and its main constituent, silymarin, as a potential therapeutic plant in metabolic syndrome: A review

Phytotherapy Research : PTR
Atefeh TajmohammadiH Hosseinzadeh

Abstract

Metabolic syndrome describes a complex metabolic risk factors including obesity, hypertension, dyslipidemia, and diabetes. This syndrome is diagnosed by medical conditions such as weight gain, high blood pressure, high blood glucose, and disturbance in lipid profile. Metabolic syndrome has become as an important and increasing global health problem, so finding potentially novel solutions with less adverse effects is favorable for health problems. Herbal therapy plays an important role for treatment of different diseases. Silybum marianum is a plant that is used for centuries as a herbal treatment in liver and biliary tract diseases. Silymarin is the main component of S. marianum and derived from fruits and seeds of S. marianum (milk thistle). S. marianum has been found to exhibit antioxidant, lipid-lowering, antihypertensive, antidiabetic, antiatherosclerotic, anti-obesity, and hepatoprotective effects. Therefore, the aim of this review is to summarize different animal and human studies regarding the effect of S. marianum in metabolic syndrome and to identify the underlying mechanisms of action.

References

Jun 5, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nina SkottováJitka Ulrichová
Sep 2, 2005·Evidence-based Complementary and Alternative Medicine : ECAM·Gholamreza KarimiZahra Tahoonian
Sep 20, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A Di SarioA Benedetti
Nov 9, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lucie SobolováKarel Urbánek
Jul 11, 2007·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J OrolinP Anzenbacher
Jul 27, 2007·Journal of Medicinal Food·Soo-Hyun KimSeung-Shi Ham
May 15, 2008·Journal of Agricultural and Food Chemistry·Sunny WallaceDanielle Julie Carrier
Apr 11, 2009·International Journal of Molecular Medicine·Sun-O KaByung-Hyun Park
Nov 4, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Yara HaddadPierre S Haddad
Jun 22, 2010·Journal of Cellular Biochemistry·Wen AiHongliang Li
Feb 18, 2011·Journal of Cellular Biochemistry·Tianzuo ZhanJoachim Füllekrug
Apr 7, 2011·Current Pharmaceutical Biotechnology·János Féher, Gabriella Lengyel
Jul 15, 2011·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Jiayin YaoChen Minhu
Jul 16, 2011·Cardiovascular Diabetology·Giovanni Li VoltiFederico Salamone
Dec 6, 2011·Chemico-biological Interactions·Carina Parisoto ColturatoJorgete Constantin
Jul 10, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mohammad Kazem FallahzadehKamran B Lankarani
Jul 26, 2012·Oxidative Medicine and Cellular Longevity·Saeid GolbidiIsmail Laher
Oct 18, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Luca CalaniDaniele Del Rio
Mar 28, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Jiayin YaoXiaobo Yang
Aug 27, 2013·Expert Opinion on Biological Therapy·Giuseppe DerosaPamela Maffioli
Nov 2, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·C SotoI González
Apr 18, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Claudia SotoSalud Pérez
Jun 1, 2014·Journal of Endocrinological Investigation·Hossein Hosseinzadeh, Marjan Nassiri-Asl
Aug 16, 2014·Journal of Endocrinological Investigation·B M Razavi, H Hosseinzadeh
Feb 1, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Angela VilligerVeronika Butterweck
Feb 14, 2015·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Francesco Di PierroPietro Putignano
Feb 18, 2015·Journal of Evidence-based Complementary & Alternative Medicine·Mahmood BahmaniMahmoud Rafieian-Kopaei
Jun 4, 2015·Journal of Endocrinological Investigation·A Hosseini, H Hosseinzadeh
Jun 13, 2015·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Martin PorubaRostislav Vecera
Jan 23, 2016·Phytotherapy Research : PTR·Maryam Akaberi, Hosein Hosseinzadeh
May 15, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Faezeh Vahdati HassaniHossein Hosseinzadeh
Nov 20, 2016·Journal of the Science of Food and Agriculture·Bibi Marjan Razavi, Hossein Hosseinzadeh
Jan 27, 2017·Phytotherapy Research : PTR·Aline Maria StolfAlexandra Acco
Feb 20, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mahdi ZarvandiAhmad Ghorbani
Apr 11, 2017·Phytotherapy Research : PTR·Jamshid TabeshpourHossein Hosseinzadeh
Dec 13, 2017·Journal of Evidence-based Complementary & Alternative Medicine·Nahid KhaliliHasan Fallah Huseini

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Citations

Apr 3, 2019·International Journal of Molecular Sciences·Almudena Pérez-SánchezJavier A Menendez
May 10, 2019·Phytotherapy Research : PTR·Vahid SoleimaniGholamreza Karimi
Feb 26, 2020·Phytotherapy Research : PTR·Farhad EisvandHossein Hosseinzadeh
May 10, 2020·Antioxidants·Antonia DiukendjievaIlza Pajeva
Mar 7, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Fernanda Caetano Camini, Daniela Caldeira Costa
Jun 11, 2019·Phytotherapy Research : PTR·Angelo A Izzo
Jan 3, 2020·European Journal of Gastroenterology & Hepatology·Eduardo E Vargas-Pozada, Pablo Muriel
Mar 30, 2020·Phytotherapy Research : PTR·Danial EsmaeilzadehHossein Hosseinzadeh
Apr 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muzamil ShahBilal Haider Abbasi
Aug 29, 2019·Phytotherapy Research : PTR·Zahra ShakibHossein Hosseinzadeh
Mar 3, 2020·Frontiers in Pharmacology·Laxman SinghAtanas G Atanasov
Jun 2, 2020·Frontiers in Bioengineering and Biotechnology·Zeinab NouriMohammad Abdollahi
Oct 6, 2020·Phytotherapy Research : PTR·Motahareh Boozari, Hossein Hosseinzadeh
Sep 21, 2020·Annals of Hepatology·Karla MacDonald-RamosMarco Cerbón
Feb 27, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mengyao ZhaoLiming Zhao
Mar 1, 2021·Tropical Animal Health and Production·Jessyca Karen PinheiroJovanna Karine Pinheiro
May 1, 2021·Nutrients·Andrea MegaAnnarosa Floreani
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zi-Wei ZhaoChi-Rei Wu
Jul 3, 2021·Pharmaceuticals·Sara VerduraJavier A Menendez
Aug 2, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mariana Carolina Di SantoOscar Edgardo Pérez
Sep 2, 2021·Brazilian Journal of Biology = Revista Brasleira De Biologia·B AhmadA A K Khalil

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