Silymarin Accelerates Liver Regeneration after Partial Hepatectomy

Evidence-based Complementary and Alternative Medicine : ECAM
Jia-Ping WuChih-Yang Huang

Abstract

Partial hepatectomy (PHx) is a liver regeneration physiological response induced to maintain homeostasis. Liver regeneration evolved presumably to protect wild animals from catastrophic liver loss caused by toxins or tissue injury. Silymarin (Sm) ability to stimulate liver regeneration has been an object of curiosity for many years. Silymarin has been investigated for use as an antioxidant and anticarcinogen. However, its use as a supportive treatment for liver damage is elusive. In this study, we fed silymarin (Sm, 25 mg/kg) to male Sprague-Dawley rats for 7 weeks. Surgical 2/3 PHx was then conducted on the rats at 6 hrs, 24 hrs, and 72 hrs. Western blot and RT-PCR were conducted to detect the cell cycle activities and silymarin effects on hepatic regeneration. The results showed that silymarin enhanced liver regeneration by accelerating the cell cycle in PHx liver. Silymarin led to increased G1 phase (cyclin D1/pRb), S phase (cyclin E/E2F), G2 phase (cyclin B), and M phase (cyclin A) protein and mRNA at 6 hrs, 24 hrs, and 72 hrs PHx. HGF, TGFα, and TGFβ1 growth factor expressions were also enhanced. We suggest that silymarin plays a crucial role in accelerated liver regeneration after PHx.

References

Dec 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N FaustoE M Webber
Apr 4, 1997·Science·G K Michalopoulos, M C DeFrances
Aug 25, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·K Wellington, B Jarvis
Dec 12, 2001·Drugs·R SallerR Brignoli
May 2, 2003·Applied Biochemistry and Biotechnology·Jose F BarretoEdgar C Clausen
Sep 3, 2003·Biochemical and Biophysical Research Communications·Jun-ichi OkanoYoshikazu Murawaki
Jan 10, 2006·International Immunopharmacology·Lin Hao LiTakashi Ikejima
Dec 1, 2006·BMC Gastroenterology·Kumar ShanmukhappaJorge A Bezerra
Jun 26, 2007·Bioscience, Biotechnology, and Biochemistry·Nobuaki OkumuraToyohiko Ariga
May 13, 2008·Cancer Letters·Kumaraguruparan Ramasamy, Rajesh Agarwal
Mar 12, 2009·Applied Biochemistry and Biotechnology·Lijun DuanDanielle Julie Carrier
Mar 18, 2010·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Tamas BenkoUrsula Rauen
Apr 7, 2011·Current Pharmaceutical Biotechnology·János Féher, Gabriella Lengyel
Jun 3, 2011·World Journal of Gastroenterology : WJG·Carmela Loguercio, Davide Festi
Jun 28, 2011·Journal of Hepatology·Yirui GuiSubburaj Ilangumaran
Nov 2, 2011·Cancer Cell International·Hala O El MesallamyMai M Abdel Moaty
Nov 19, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tsuyoshi IshikawaSnorri S Thorgeirsson
Feb 22, 2012·Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·Frank J BurczynskiYuewen Gong
Feb 1, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Chin-Chuan TsaiChih-Yang Huang
Aug 26, 2014·Pharmacological Reports : PR·Nitesh KumarC Mallikarjuna Rao
Sep 23, 2014·European Journal of Pharmacology·Li FanGuangrong Huang
Nov 29, 2014·Pharmaceutical Biology·Mina KhoshnoodiAhmad Reza Dehpour
Dec 30, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mustafa CengizAdnan Ayhancı

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Citations

Mar 11, 2017·Canadian Journal of Physiology and Pharmacology·Mozhgan Ghobadi PourAlireza Monsef Esfahani
Jan 16, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Evidence-Based Complementary And Alternative Medicine
Sep 28, 2017·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Alexandra K TsarouchaConstantinos E Simopoulos
Apr 1, 2021·BMC Complementary Medicine and Therapies·Tewodros MengeshaTsegaye Mehare

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Methods Mentioned

BETA
surgical resection
PCR
electrophoresis
Fluorescence

Software Mentioned

SigmaStat
FUJIFILM Imagine

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