Silymarin nanoemulsion against human hepatocellular carcinoma: development and optimization

Artificial Cells, Nanomedicine, and Biotechnology
Usama AhmadSahabjada Siddiqui

Abstract

Nanoemulsion of silymarin was developed and optimized. Nanoemulsion was made by aqueous titration method. Sefsol 218 (5.8% v/v), Kolliphor RH40 and polyethylene glycol 400 (Smix; 2:1; 28.99% v/v) were used as oil phase, surfactant and co-surfactant while distilled water (65.22% v/v) acted as an aqueous phase. Nanoemulsion was characterized on the basis of particle size, viscosity, electrical conductivity and refractive index. Further, in vitro release, in vivo pharmacokinetic study, stability study and cancer cell line studies were also performed. The optimized formulation (NE9) with mean particle size of 21.24 nm showed a minimum viscosity of 9.59 cps, maximum drug release (97.75%) in 24 h. The NE9 formulation also showed higher AUC (p < .01) and Cmax (p < .01) and shorter Tmax (p < .05) compared with conventional and standard suspensions of silymarin. The stability study also showed considerably stable formulations at refrigerator temperature as compared with room temperature (p > .05). The cancer cell line studies also confirmed that silymarin nanoemulsion reduced the cell viability and increased ROS intensity and chromatin condensation (p < .05). Our results concluded that nanoemulsion may be an efficient carrier for oral d...Continue Reading

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Citations

Sep 9, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Afreen UsmaniMohd Ahmad
Jun 11, 2020·Current Pharmaceutical Design·Phui Qi NgDinesh Kumar Chellappan
Jan 25, 2020·Anti-cancer Agents in Medicinal Chemistry·Diana S AntalCristina Dehelean
Jun 23, 2021·Drug Research·Sushmita SrivastavaAsad Ali

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