Silymarin Prevents Memory Impairments, Anxiety, and Depressive-Like Symptoms in a Rat Model of Post-Traumatic Stress Disorder

Planta medica
Tamam El-ElimatNicholas H Oberlies

Abstract

Post-traumatic stress disorder (PTSD) is a debilitating psychopathological disease that is triggered by exposure to traumatic events. It is usually associated with substantial comorbidities, such as cognitive impairment, anxiety, and depression. Silymarin has been recently reported to exert neuroprotective activities against neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Herein, the beneficial effects of silymarin in ameliorating PTSD-like symptoms such as memory impairments, anxiety, and depression were evaluated using a single-prolonged stress (SPS) rat model of PTSD. Male Wistar rats were randomly assigned into four groups: control, silymarin, SPS, or SPS + silymarin. Rats were administrated silymarin, 100 mg/kg i. p. for 4 wk. Rats in all groups were tested for short- and long-term memory in the radial arm water maze (RAWM), for anxiety-like behaviors using the open field test (OFT) and elevated plus maze (EPM) test, and for depression-like symptoms using the tail suspension test (TST). Conventional analyses of the RAWM, EPM, OFT, and TST were conducted using analysis of variance. Additionally, the anxiety-related behavior parameters of the EPM and OFT were entered to principal component analysis. ...Continue Reading

Citations

Mar 5, 2019·Behavioural Pharmacology·Karem H AlzoubiMahmoud A Alfaqih
May 3, 2019·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Mi LiYong Jiang
Dec 10, 2019·Stress : the International Journal on the Biology of Stress·Mengfei HanXigeng Zheng
Nov 13, 2019·Behavioural Brain Research·Karem H AlzoubiMahmoud A Alfaqih
Apr 19, 2019·Life Sciences·Karem H AlzoubiHamza I Abu Zamzam
Jun 11, 2021·Physiological Reports·Mahmoud A AlomariOmar F Khabour

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