PMID: 9639069Jun 25, 1998Paper

Simian immunodeficiency virus encephalitis in rhesus macaques is associated with rapid disease progression

Journal of Neurovirology
Susan WestmorelandAndrew A Lackner

Abstract

Central nervous system (CNS) disease is a major feature of simian immunodeficiency virus (SIV) infection of macaques. To define the spectrum of CNS lesions in SIV-infected macaques and the potential associations with viral strain and disease course, we performed a retrospective analysis of necropsies on 124 macaques with SIV-induced AIDS. Histologic evidence of CNS disease was observed in 71 (57.3%) of the 124 animals. SIV encephalitis was the most common CNS lesion occurring in 43.7% (31/71) of the animals with CNS disease and 25% of all animals. The incidence of SIVE correlated significantly with shortened survival (P=0.0207). In addition, SIVE was seen in 42.9% (15/35) of rapid progressors (animals that died within 200 days) compared to only 18% (16/89) of normal progressors (animals that lived longer than 200 days) (P=0.011). Animals with SIVE had higher viral loads in peripheral blood than those that did not, but this difference did not reach statistical significance. Similarly, while animals infected with uncloned SIVmac251 had a higher incidence of SIVE (27.5%; 14/51) than animals infected with molecularly cloned SIVmac239 and its T-cell tropic derivatives (18.5%; 10/54) this difference was not statistically significant....Continue Reading

Citations

Dec 15, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Kenneth Williams, Tricia H Burdo
Mar 14, 2002·The American Journal of Pathology·Stephanie J BisselClayton A Wiley
Sep 10, 2008·Journal of Neurovirology·Howard S Fox
Sep 10, 2008·Journal of Neurovirology·Leslie CrewsEliezer Masliah
Aug 24, 2000·AIDS Research and Human Retroviruses·L A RaymondP D Cheney
Jan 12, 2001·AIDS·R G GonzálezA A Lackner
Oct 17, 2006·Clinical Microbiology Reviews·Sue VandeWoude, Cristian Apetrei
Jan 16, 2007·Annual Review of Medicine·Andrew A Lackner, Ronald S Veazey
Jun 8, 2002·Annual Review of Neuroscience·Kenneth C Williams, William F Hickey
Mar 14, 2013·BioMed Research International·Maria Cecilia Garibaldi MarcondesHoward Fox
Aug 20, 2005·The Journal of Clinical Investigation·Kenneth WilliamsR Gilberto González
Apr 9, 2004·BMC Neuroscience·Robert A FullerR Gilberto González
Sep 13, 2014·Future Virology·Tricia H Burdo, Andrew D Miller
Apr 27, 2012·Journal of Neurovirology·Nicole A RennerAndrew G MacLean
Apr 30, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Kenneth C Williams, Tricia H Burdo
Jun 19, 2013·Immunological Reviews·Tricia H BurdoKenneth C Williams
Dec 8, 2004·The American Journal of Pathology·Juan T BordaAndrew A Lackner
Aug 2, 2014·Journal of Medical Primatology·Keiko Y PetroskyAndrew D Miller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.