Simian immunodeficiency virus-induced intestinal cell apoptosis is the underlying mechanism of the regenerative enteropathy of early infection

The Journal of Infectious Diseases
Qingsheng LiAshley T Haase

Abstract

The enteropathic manifestations of the human immunodeficiency virus (HIV) and the simian immunodeficiency virus (SIV) in late infection are usually due to infection by other microbes, but in early infection the viruses themselves cause an enteropathy by heretofore undetermined mechanisms. Here we report that SIV induces massive apoptosis of intestinal epithelial cells lining the small and large bowel, thus identifying apoptosis as the driving force behind the regenerative pathology of early infection. We found that apoptosis of gut epithelium paralleled the previously documented apoptosis and massive depletion of CD4 T cells in gut lamina propria, triggered by established mechanisms of gut epithelial cell apoptosis and, at peak, possibly by virus interactions with GPR15/Bob, an intestinal epithelial cell-associated alternative coreceptor for SIV and HIV-1. Apoptosis in early SIV infection is thus the common theme of the pathological processes that quickly afflict the innate as well as adaptive arms of the gut immune system.

References

Oct 1, 1984·Annals of Internal Medicine·D P KotlerP R Holt
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·A L EdingerR W Doms
Feb 3, 1999·Annals of the New York Academy of Sciences·M ZeitzE O Riecken
Apr 11, 2001·American Journal of Clinical Pathology·R CiccocioppoG R Corazza
Nov 7, 2001·The American Journal of Pathology·F ClaytonJ Fantini
Jul 4, 2002·The American Journal of Gastroenterology·Johannes GrossmannJürgen Schölmerich
Jul 2, 2003·Nature Medicine·Melissa Pope, Ashley T Haase
Jan 26, 2005·AIDS·Donald P Kotler
Feb 3, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Hana HolubecHarinder Garewal
Mar 26, 2005·Science·Freddy Radtke, Hans Clevers
Jul 5, 2005·Journal of Virology·Christopher J MillerAshley T Haase
Oct 4, 2005·Nature Reviews. Immunology·Ashley T Haase
Feb 17, 2006·Nature Immunology·Jason M BrenchleyDaniel C Douek
Nov 23, 2006·Nature Medicine·Jason M BrenchleyDaniel C Douek

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Citations

Apr 25, 2012·Current HIV/AIDS Reports·Peter W Hunt
Oct 8, 2008·Trends in Immunology·Igor M Belyakov, Jeffrey D Ahlers
Aug 27, 2009·Nature Reviews. Gastroenterology & Hepatology·Siew C Ng, Brian Gazzard
Jul 5, 2008·The Journal of Infectious Diseases·Sarah W Read, Irini Sereti
Mar 27, 2009·AIDS Research and Human Retroviruses·Susan M GrahamJulie Overbaugh
Jan 22, 2011·The Journal of Infectious Diseases·Netanya G SandlerUNKNOWN INSIGHT SMART Study Group
Mar 24, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ferdinand MaingatChristopher Power
Jun 15, 2010·Current Opinion in HIV and AIDS·Peter W Hunt
Jan 9, 2013·Clinical Microbiology Reviews·Giulia MarchettiGuido Silvestri
May 22, 2009·Journal of Virology·Matthew D H LayMiles P Davenport
Jan 10, 2012·Annual Review of Immunology·Jason M Brenchley, Daniel C Douek
Oct 25, 2008·Annual Review of Medicine·Daniel C DouekRichard A Koup
Dec 14, 2011·The Journal of Clinical Investigation·Maud MavignerPierre Delobel
Jul 4, 2012·BMC Complementary and Alternative Medicine·Marco SchunterJ William Critchfield
Jul 1, 2011·Future Virology·Maile Ay Karris, Davey M Smith
Jan 7, 2014·Current HIV/AIDS Reports·Amanda L Willig, E Turner Overton
Oct 30, 2014·AIDS Research and Human Retroviruses·Jordan PolesCatarina E Hioe
Jun 27, 2012·Annals of the New York Academy of Sciences·Hans-Jörg Epple, Martin Zeitz
Feb 5, 2015·Cardiology Research and Practice·Akram M ZaaqoqRoger D Smalligan
Jul 14, 2010·Immunity·Jason M BrenchleyDaniel C Douek
Apr 15, 2014·Cytokine·Alison CartwrightJim Middleton

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis