PMID: 8607276Feb 15, 1996Paper

Simian immunodeficiency virus (SIV) gp130 oligomers protect rhesus macaques (Macaca mulatta) against the infection with SIVmac32H grown on T-cells or derived ex vivo

Virology
W LükeG Hunsmann

Abstract

The efficacy of three SIVmac32H gp130 vaccines was compared in rhesus monkeys. Three rhesus monkeys were each immunized over a period of 20 weeks with a total of 600 microgram virion-derived gp130 oligomers (O-gp130) mixed with keyhole limpet hemocyanin and emulsified with incomplete Freund's adjuvant. Three other monkeys were infected with 5 x 10(8) PFU of vaccinia virus wild type (VV-wt) while three additional animals received an equivalent dose of VV expressing the gp130 of SIVmac (VV-gp130). At Week 8, the two VV-wt animals received an additional immunization with 100 microgram O-gp130 each. All VV-infected animals then received booster immunizations at Weeks 12, 16, and 20 with a total of 300 microgram O-gp130 per animal. All animals along with two controls were challenged iv with 50 MID50 of T-cell-grown SIVmac32H at Week 22. Four weeks after the challenge and thereafter, both controls and one animal from either VV group were infected as demonstrated by polymerase chain reaction (PCR), virus isolation, and antibody response. In contrast, all O-gp130 animals and one animal each from the VV-wt and the VV-gp130 group were completely protected as shown by negative PCR and virus reisolation. One animal of the VV-gp130 group wa...Continue Reading

Citations

Nov 14, 1997·AIDS Research and Human Retroviruses·H PetryW Lüke
Sep 25, 2002·Clinics in Laboratory Medicine·James P McGettiganMatthias J Schnell
Nov 13, 2009·Journal of Peptide Science : an Official Publication of the European Peptide Society·Fabrice GastonElmostafa Bahraoui
Dec 22, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·H PetryW Lüke
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thorsten MühlUlrike Sauermann
Jan 28, 1998·Journal of Virology·R C DesrosiersR P Johnson

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